The Fe O @SiO /Salen-Cu(II) nanocatalyst is reported as a thermally and air-stable, economical, and magnetically 3 4 2 recoverable heterogeneous catalyst for the selective and efﬁcient N-(hetero)arylation of imidazole. Only by adding a small amount of the catalyst (0.4 mol% Cu) to the reactants and heating under air, the new presented method provides a variety of functionalized and hindered N-(hetero)arylimidazoles in good to excellent yields within short reaction times. The catalyst could be easily recovered with the aid of a permanent magnet and reused up to ﬁve consecutive runs without signiﬁcant loss of activity. Also, the leaching of Cu was negligible after the ﬁfth recycle. Particularly, using either (hetero)aryl iodides or bromides as arylating agents and the need of only small amount of the magnetically recoverable heterogeneous copper-based nanocatalyst make this method low-cost, environmentally benign, and easy to use. Graphical abstract Keywords N-Arylation Aryl halides Heterogeneous catalysis Magnetic properties Nanostructures Salen-Cu(II) Introduction Taking a look at the literature, we will ﬁnd out that N- heterocyclic compounds are prevalent structural motifs in biological, pharmaceutical, chemical, and material ﬁelds [1–3]. Among these, imidazole derivatives are utilized not only in medicinal ﬁeld as cardiotonic, antiglaucoma, Electronic
Monatshefte für Chemie - Chemical Monthly – Springer Journals
Published: Feb 14, 2018
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