A mild and efﬁcient protocol for the one-pot synthesis of 4-amidocinnolines was developed using saccharin as a cheap and eco-friendly organocatalyst and t-butyl nitrite as a metal-free diazotization reagent. The current method has advantages such as cost effectiveness, use of the biodegradable reagents, simple experimental procedure; afford the quantitative yield of the desired products, metal- and halogen-free as well as environmentally benign conditions. Graphical abstract NH 3 R 2 R N O NH r.t., 6 h BuONO(1.5 equiv) R Sac-H (20 mol%) 62-88 % isolated yield Keywords Saccharin t-Butyl nitrite Cinnoline Metal-free condition One-pot synthesis Introduction potential accidents, preparing the biodegradable or recy- clable products, using sustainable raw materials, and The reduction of environmental, human health, and safety avoiding molecules linked to toxicity are some routes in risks of chemicals and synthetic procedures is the foremost green chemistry. New reagents and catalysts, low-risk goal of green chemistry that can be achieved by solvents and experimental processes, are developed by redesigning synthetic and industrial procedures. Reducing green chemistry researchers . the amount of waste generated in reactions, recycling Cinnolines and their derivatives are a great important certain reagents, improving energy efﬁciency, minimizing aza-heterocycles of pharmaceutical cores
Monatshefte für Chemie - Chemical Monthly – Springer Journals
Published: Feb 21, 2018
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