RRx-001 protects against cisplatin-induced toxicities

RRx-001 protects against cisplatin-induced toxicities J Cancer Res Clin Oncol (2017) 143:1671–1677 DOI 10.1007/s00432-017-2416-4 ORIGINAL ARTICLE – CANCER RESEARCH 1 3 3 4 Bryan Oronsky · Tony R. Reid · Christopher Larson · Corey A. Carter · 4 5 2 Christina E. Brzezniak · Arnold Oronsky · Pedro Cabrales Received: 10 March 2017 / Accepted: 30 March 2017 / Published online: 17 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract spreads were prepared from whole bone marrow cells as Purpose RRx-001, a minimally toxic tumor-associated markers of clastogenicity. macrophage and neutrophil-repolarizing agent, is under Results RRx-001 pretreatment significantly decreased investigation in Phase II clinical trials as a sensitizer/resen- (P < 0.05) the blood urea nitrogen and creatinine levels. sitizer to cisplatin and carboplatin. On the basis of anecdo- A statistically significant ( P < 0.05) reduction in the mean tal clinical observations of improved platinum tolerability total chromosome aberration frequency per metaphase in following a priming period with RRx-001 as well as pre- the RRx-001 and cisplatin group compared to the cisplatin- clinical studies that have previously demonstrated radiopro- only group was observed. tection of intestinal stem cells and cardioprotection from Conclusions This study is the first to demonstrate that doxorubicin, the in vivo http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cancer Research and Clinical Oncology Springer Journals

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Oncology; Cancer Research; Internal Medicine; Hematology
ISSN
0171-5216
eISSN
1432-1335
D.O.I.
10.1007/s00432-017-2416-4
Publisher site
See Article on Publisher Site

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