RRx-001 protects against cisplatin-induced toxicities

RRx-001 protects against cisplatin-induced toxicities J Cancer Res Clin Oncol (2017) 143:1671–1677 DOI 10.1007/s00432-017-2416-4 ORIGINAL ARTICLE – CANCER RESEARCH 1 3 3 4 Bryan Oronsky · Tony R. Reid · Christopher Larson · Corey A. Carter · 4 5 2 Christina E. Brzezniak · Arnold Oronsky · Pedro Cabrales Received: 10 March 2017 / Accepted: 30 March 2017 / Published online: 17 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract spreads were prepared from whole bone marrow cells as Purpose RRx-001, a minimally toxic tumor-associated markers of clastogenicity. macrophage and neutrophil-repolarizing agent, is under Results RRx-001 pretreatment significantly decreased investigation in Phase II clinical trials as a sensitizer/resen- (P < 0.05) the blood urea nitrogen and creatinine levels. sitizer to cisplatin and carboplatin. On the basis of anecdo- A statistically significant ( P < 0.05) reduction in the mean tal clinical observations of improved platinum tolerability total chromosome aberration frequency per metaphase in following a priming period with RRx-001 as well as pre- the RRx-001 and cisplatin group compared to the cisplatin- clinical studies that have previously demonstrated radiopro- only group was observed. tection of intestinal stem cells and cardioprotection from Conclusions This study is the first to demonstrate that doxorubicin, the in vivo http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cancer Research and Clinical Oncology Springer Journals

Loading next page...
Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Medicine & Public Health; Oncology; Cancer Research; Internal Medicine; Hematology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial