Rotavirus infections with multiple emerging genotypes in Sri Lanka

Rotavirus infections with multiple emerging genotypes in Sri Lanka Rotavirus diarrhea is an important cause of child mortality in developing countries, but studies on this diarrhea are scarce in Sri Lanka. A prospective study conducted in Sri Lanka on rotavirus infection among children in a hospital setting ( n = 611) versus children residing in tsunami camps ( n = 52) showed that prevalence of rotavirus infection was comparable, 21.9 and 20%, respectively. The hospital and camps were located in different districts. Analysis of the genotypes of 122 rotaviruses from the hospital and 12 from the camps indicated that G9P(8) was associated with 35 and 33%; G12P(8/nt) with 14.7 and 33%; G3P(8/4/nt) with 17 and 8% and G1P(8/4) with 6.5 and 16.7%. Rotaviruses with G2P(8/4/6) and G4P(8/4) were hospital-associated only, and some rotaviruses (9 and 8% from the hospital and the camps, respectively) were G- and P-nontypable. We conclude from the present study that multiple emerging genotypes were prevalent in Sri Lanka, and children in camps were at risk of developing diarrhea due to rotaviruses. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals
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Publisher
Springer Vienna
Copyright
Copyright © 2010 by Springer-Verlag
Subject
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-009-0552-0
Publisher site
See Article on Publisher Site

Abstract

Rotavirus diarrhea is an important cause of child mortality in developing countries, but studies on this diarrhea are scarce in Sri Lanka. A prospective study conducted in Sri Lanka on rotavirus infection among children in a hospital setting ( n = 611) versus children residing in tsunami camps ( n = 52) showed that prevalence of rotavirus infection was comparable, 21.9 and 20%, respectively. The hospital and camps were located in different districts. Analysis of the genotypes of 122 rotaviruses from the hospital and 12 from the camps indicated that G9P(8) was associated with 35 and 33%; G12P(8/nt) with 14.7 and 33%; G3P(8/4/nt) with 17 and 8% and G1P(8/4) with 6.5 and 16.7%. Rotaviruses with G2P(8/4/6) and G4P(8/4) were hospital-associated only, and some rotaviruses (9 and 8% from the hospital and the camps, respectively) were G- and P-nontypable. We conclude from the present study that multiple emerging genotypes were prevalent in Sri Lanka, and children in camps were at risk of developing diarrhea due to rotaviruses.

Journal

Archives of VirologySpringer Journals

Published: Jan 1, 2010

References

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