A collection of rotavirus samples collected over a 26-year period was examined to study the dynamics of change in RV strains of genotype P(8) in a geographically defined population (Nizhny Novgorod, Russia; children under 6 years) with no vaccine pressure. Phylogenetic analysis of gene VP4 (subunit VP8*) showed the presence of two lines of genotype P(8): P(8)-1 and P(8)-3. Since 1997, the dominant population of rotavirus has been occupied by strains carrying the allele P(8)-3, which is associated with G1, G3 and G4. The complete replacement of the allele P(8)-1 to P(8)-3 took 19 epidemic years.
Archives of Virology – Springer Journals
Published: Dec 1, 2012
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