ROS-modulated therapeutic approaches in cancer treatment

ROS-modulated therapeutic approaches in cancer treatment J Cancer Res Clin Oncol (2017) 143:1789–1809 DOI 10.1007/s00432-017-2464-9 REVIEW – CLINICAL ONCOLOGY 1 2 3 4 Muhammad Hassan Raza · Sami Siraj · Abida Arshad · Usman Waheed · 5 6 1 Fahad Aldakheel · Shatha Alduraywish · Muhammad Arshad Received: 27 May 2017 / Accepted: 16 June 2017 / Published online: 24 June 2017 © Springer-Verlag GmbH Germany 2017 Abstract Results This review highlights oxidative stress in tumors, Purpose Reactive oxygen species (ROS) are produced in underlying mechanisms of different relationships of ROS cancer cells as a result of increased metabolic rate, dysfunc- and cancer cells, different ROS-mediated therapeutic strate- tion of mitochondria, elevated cell signaling, expression of gies and the emerging role of microbiota in cancer therapy. oncogenes and increased peroxisome activities. Certain Conclusion Cancer cells exhibit increased ROS stress and level of ROS is required by cancer cells, above or below disturbed redox homeostasis which lead to ROS adapta- which lead to cytotoxicity in cancer cells. This biochemical tions. ROS-dependent anticancer therapies including ROS aspect can be exploited to develop novel therapeutic agents scavenging anticancer therapy and ROS boosting antican- to preferentially and selectively target cancer cells. cer therapy have shown promising results in vitro Journal of Cancer Research and Clinical Oncology Springer Journals

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Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag GmbH Germany
Medicine & Public Health; Oncology; Cancer Research; Internal Medicine; Hematology
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