ROS-modulated therapeutic approaches in cancer treatment

ROS-modulated therapeutic approaches in cancer treatment J Cancer Res Clin Oncol (2017) 143:1789–1809 DOI 10.1007/s00432-017-2464-9 REVIEW – CLINICAL ONCOLOGY 1 2 3 4 Muhammad Hassan Raza · Sami Siraj · Abida Arshad · Usman Waheed · 5 6 1 Fahad Aldakheel · Shatha Alduraywish · Muhammad Arshad Received: 27 May 2017 / Accepted: 16 June 2017 / Published online: 24 June 2017 © Springer-Verlag GmbH Germany 2017 Abstract Results This review highlights oxidative stress in tumors, Purpose Reactive oxygen species (ROS) are produced in underlying mechanisms of different relationships of ROS cancer cells as a result of increased metabolic rate, dysfunc- and cancer cells, different ROS-mediated therapeutic strate- tion of mitochondria, elevated cell signaling, expression of gies and the emerging role of microbiota in cancer therapy. oncogenes and increased peroxisome activities. Certain Conclusion Cancer cells exhibit increased ROS stress and level of ROS is required by cancer cells, above or below disturbed redox homeostasis which lead to ROS adapta- which lead to cytotoxicity in cancer cells. This biochemical tions. ROS-dependent anticancer therapies including ROS aspect can be exploited to develop novel therapeutic agents scavenging anticancer therapy and ROS boosting antican- to preferentially and selectively target cancer cells. cer therapy have shown promising results in vitro http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cancer Research and Clinical Oncology Springer Journals

Loading next page...
 
/lp/springer_journal/ros-modulated-therapeutic-approaches-in-cancer-treatment-vKRKWFxPog
Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Medicine & Public Health; Oncology; Cancer Research; Internal Medicine; Hematology
ISSN
0171-5216
eISSN
1432-1335
D.O.I.
10.1007/s00432-017-2464-9
Publisher site
See Article on Publisher Site

Abstract

J Cancer Res Clin Oncol (2017) 143:1789–1809 DOI 10.1007/s00432-017-2464-9 REVIEW – CLINICAL ONCOLOGY 1 2 3 4 Muhammad Hassan Raza · Sami Siraj · Abida Arshad · Usman Waheed · 5 6 1 Fahad Aldakheel · Shatha Alduraywish · Muhammad Arshad Received: 27 May 2017 / Accepted: 16 June 2017 / Published online: 24 June 2017 © Springer-Verlag GmbH Germany 2017 Abstract Results This review highlights oxidative stress in tumors, Purpose Reactive oxygen species (ROS) are produced in underlying mechanisms of different relationships of ROS cancer cells as a result of increased metabolic rate, dysfunc- and cancer cells, different ROS-mediated therapeutic strate- tion of mitochondria, elevated cell signaling, expression of gies and the emerging role of microbiota in cancer therapy. oncogenes and increased peroxisome activities. Certain Conclusion Cancer cells exhibit increased ROS stress and level of ROS is required by cancer cells, above or below disturbed redox homeostasis which lead to ROS adapta- which lead to cytotoxicity in cancer cells. This biochemical tions. ROS-dependent anticancer therapies including ROS aspect can be exploited to develop novel therapeutic agents scavenging anticancer therapy and ROS boosting antican- to preferentially and selectively target cancer cells. cer therapy have shown promising results in vitro

Journal

Journal of Cancer Research and Clinical OncologySpringer Journals

Published: Jun 24, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off