Role of TIM-3 in ovarian cancer

Role of TIM-3 in ovarian cancer Evidences have suggested that immunotherapy for ovarian cancer is effective. Immune checkpoints have emerged in the field of cancer immunotherapy. Multiple studies have shown negative regulation of TIM-3 expression on CD4+ and CD8+ T cells and other immunocytes. Overexpression of TIM-3 in innate immune cells has been found in certain types of tumor. The blockade of TIM-3 leads to sustained anti-tumor reactions. TIM-3 plays an inhibitive role for immunity in ovarian cancer. TIM-3 is involved in the development of various subtypes of ovarian cancer and thus has the potential to be a therapeutic target for treatment of ovarian cancer. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Translational Oncology Springer Journals

Role of TIM-3 in ovarian cancer

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/lp/springer_journal/role-of-tim-3-in-ovarian-cancer-6sP7k00c3Z
Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Federación de Sociedades Españolas de Oncología (FESEO)
Subject
Medicine & Public Health; Oncology
ISSN
1699-048X
eISSN
1699-3055
D.O.I.
10.1007/s12094-017-1656-8
Publisher site
See Article on Publisher Site

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