Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats

Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats Rationale Environmental stimulus control over drug relapse but not the SSJ, attenuated drug context-induced reinstatement requires the retrieval of context-response-cocaine associa- of cocaine-seeking behavior without altering locomotor activ- tions, maintained in long-term memory through active ity. Conversely, AI inactivation after memory reactivation reconsolidation processes. Identifying the neural substrates failed to impair subsequent drug-seeking behavior and thus of these phenomena is important from a drug addiction treat- cocaine memory reconsolidation. Conclusions These findings suggest that the AI is a critical ment perspective. Objectives The present study evaluated whether the agranular element of the neural circuitry that mediates contextual control insular cortex (AI) plays a role in drug context-induced co- over cocaine-seeking behavior. caine-seeking behavior and cocaine memory reconsolidation. . . Methods Rats were trained to lever press for cocaine infusions Keywords Memory reconsolidation Context Cocaine . . . in a distinctive context, followed by extinction training in a seeking Agranular insular cortex Self-administration different context. Rats in experiment 1 received bilateral Baclofen muscimol Reinstatement microinfusions of vehicle or a GABA agonist cocktail (baclo- fen and muscimol (BM)) into the AI or the overlying somato- sensory cortex (SSJ, anatomical control region) immediately Introduction before a test of drug-seeking behavior (i.e., non-reinforced http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats

Loading next page...
 
/lp/springer_journal/role-of-the-agranular-insular-cortex-in-contextual-control-over-kwhM0vkzqo
Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/s00213-017-4632-7
Publisher site
See Article on Publisher Site

Abstract

Rationale Environmental stimulus control over drug relapse but not the SSJ, attenuated drug context-induced reinstatement requires the retrieval of context-response-cocaine associa- of cocaine-seeking behavior without altering locomotor activ- tions, maintained in long-term memory through active ity. Conversely, AI inactivation after memory reactivation reconsolidation processes. Identifying the neural substrates failed to impair subsequent drug-seeking behavior and thus of these phenomena is important from a drug addiction treat- cocaine memory reconsolidation. Conclusions These findings suggest that the AI is a critical ment perspective. Objectives The present study evaluated whether the agranular element of the neural circuitry that mediates contextual control insular cortex (AI) plays a role in drug context-induced co- over cocaine-seeking behavior. caine-seeking behavior and cocaine memory reconsolidation. . . Methods Rats were trained to lever press for cocaine infusions Keywords Memory reconsolidation Context Cocaine . . . in a distinctive context, followed by extinction training in a seeking Agranular insular cortex Self-administration different context. Rats in experiment 1 received bilateral Baclofen muscimol Reinstatement microinfusions of vehicle or a GABA agonist cocktail (baclo- fen and muscimol (BM)) into the AI or the overlying somato- sensory cortex (SSJ, anatomical control region) immediately Introduction before a test of drug-seeking behavior (i.e., non-reinforced

Journal

PsychopharmacologySpringer Journals

Published: May 2, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off