Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats

Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats Rationale Environmental stimulus control over drug relapse but not the SSJ, attenuated drug context-induced reinstatement requires the retrieval of context-response-cocaine associa- of cocaine-seeking behavior without altering locomotor activ- tions, maintained in long-term memory through active ity. Conversely, AI inactivation after memory reactivation reconsolidation processes. Identifying the neural substrates failed to impair subsequent drug-seeking behavior and thus of these phenomena is important from a drug addiction treat- cocaine memory reconsolidation. Conclusions These findings suggest that the AI is a critical ment perspective. Objectives The present study evaluated whether the agranular element of the neural circuitry that mediates contextual control insular cortex (AI) plays a role in drug context-induced co- over cocaine-seeking behavior. caine-seeking behavior and cocaine memory reconsolidation. . . Methods Rats were trained to lever press for cocaine infusions Keywords Memory reconsolidation Context Cocaine . . . in a distinctive context, followed by extinction training in a seeking Agranular insular cortex Self-administration different context. Rats in experiment 1 received bilateral Baclofen muscimol Reinstatement microinfusions of vehicle or a GABA agonist cocktail (baclo- fen and muscimol (BM)) into the AI or the overlying somato- sensory cortex (SSJ, anatomical control region) immediately Introduction before a test of drug-seeking behavior (i.e., non-reinforced Psychopharmacology Springer Journals

Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats

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Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
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