Role of PTH in Bone Marrow Niche and HSC Regulation

Role of PTH in Bone Marrow Niche and HSC Regulation Curr Stem Cell Rep (2017) 3:210–217 DOI 10.1007/s40778-017-0091-7 CELL:CELL INTERACTIONS IN STEM CELL MAINTENANCE (D BONNET, SECTION EDITOR) 1 1 2 1 Maria Giovanna Sabbieti & Luigi Marchetti & Roberta Censi & Giovanna Lacava & Dimitrios Agas Published online: 10 July 2017 Springer International Publishing AG 2017 . . . Abstract Keywords PTH PTHrP Bone marrow niche Purpose of Review Thebonemarrowmicroenvironment Hematopoiesis HSCs hosts a multicellular complex that is extraordinary in its inter- dependence and function. The composite machinery within the axial and long bones is involved in the homing, mainte- Introduction: the Current Understanding of Bone nance, differentiation, and egress of hematopoietic/ Marrow Structure and Function progenitors stem cells (HSCS) as well as mesenchymal/ stromal stem cells (MSCs) that dwell in specific anatomical The structure and function of the bone marrow have been the areas inside the marrow space, described as niches. The need object of scientific research for many decades. Certainly, the for more efficient hematopoietic stem cell transplantation pro- study of the elegant equilibrium between the different habitats tocols and bone marrow manipulation techniques has motivat- of the bone marrow reservoir presents a complex challenge. ed scientists to identify effective niche regulators such as the Specialized Current Stem Cell Reports Springer Journals

Role of PTH in Bone Marrow Niche and HSC Regulation

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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG
Life Sciences; Cell Biology; Stem Cells
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