Curr Stem Cell Rep (2017) 3:210–217 DOI 10.1007/s40778-017-0091-7 CELL:CELL INTERACTIONS IN STEM CELL MAINTENANCE (D BONNET, SECTION EDITOR) 1 1 2 1 Maria Giovanna Sabbieti & Luigi Marchetti & Roberta Censi & Giovanna Lacava & Dimitrios Agas Published online: 10 July 2017 Springer International Publishing AG 2017 . . . Abstract Keywords PTH PTHrP Bone marrow niche Purpose of Review Thebonemarrowmicroenvironment Hematopoiesis HSCs hosts a multicellular complex that is extraordinary in its inter- dependence and function. The composite machinery within the axial and long bones is involved in the homing, mainte- Introduction: the Current Understanding of Bone nance, differentiation, and egress of hematopoietic/ Marrow Structure and Function progenitors stem cells (HSCS) as well as mesenchymal/ stromal stem cells (MSCs) that dwell in specific anatomical The structure and function of the bone marrow have been the areas inside the marrow space, described as niches. The need object of scientific research for many decades. Certainly, the for more efficient hematopoietic stem cell transplantation pro- study of the elegant equilibrium between the different habitats tocols and bone marrow manipulation techniques has motivat- of the bone marrow reservoir presents a complex challenge. ed scientists to identify effective niche regulators such as the Specialized
Current Stem Cell Reports – Springer Journals
Published: Jul 10, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera