J Interv Card Electrophysiol (2017) 49:263–270 DOI 10.1007/s10840-017-0260-8 REVIEWS Role of implantable cardioverter defibrillator in non-ischemic cardiomyopathy: a systematic review and meta-analysis of prospective randomized clinical trials 1 2 3 1 Jorge Romero & Rahul Chaudhary & Jalaj Garg & Florentino Lupercio & 3 4 3 3 1,5 Neeraj Shah & Rahul Gupta & Talha Nazir & Babak Bozorgnia & Andrea Natale & 1,5 Luigi Di Biase Received: 10 January 2017 /Accepted: 30 May 2017 /Published online: 3 July 2017 Springer Science+Business Media New York 2017 Abstract Results We analyzed a total of 2573 patients from five RCTs Introduction A mortality benefit in patients with implantable comparing ICD with medical therapy in patients with NICM. cardioverter defibrillator (ICD) in ischemic cardiomyopathy is The mean follow up for the trials was 48 ± 22 months. There well established. However, the benefit of ICD implantation in was a significant reduction in (a) all-cause mortality (RR 0.84, non-ischemic cardiomyopathy (NICM) on total mortality re- 95% CI 0.71–0.99, p = 0.03) and (b) sudden cardiac death (RR mains uncertain. We performed a systematic review and meta- 0.47, 95% CI 0.30–0.73, p < 0.001) in ICD group versus medical analysis of randomized controlled trials
Journal of Interventional Cardiac Electrophysiology – Springer Journals
Published: Jul 3, 2017
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