A review of recent data concerning the apoptotic death of cells during senescence at the organismic level. The data analyzed suggest interrelations between apoptosis deregulation and some age-related pathologies and senescent phenotypes. Genetic aspects and possible mechanisms of age-related changes in the program of apoptosis are considered. It has been proposed that age-related deregulation of apoptosis is a mechanism of senescence.
Russian Journal of Developmental Biology – Springer Journals
Published: Oct 9, 2004
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