Background There are only limited data on the failure patterns after surgical resection for duodenal cancer, and the role of adjuvant chemoradiotherapy (CRT) also remains controversial. In this study, the treatment outcomes of surgery alone were compared to those of surgery plus adjuvant CRT for duodenal cancer. Methods Between January 1991 and February 2013, a total of 47 patients with duodenal cancer had pancre- aticoduodenectomy, and their age ranged from 31 to 80 (median 62). Twenty-ﬁve patients (53%) underwent surgery alone, while 22 (47%) underwent surgery plus adjuvant CRT. Postoperative radiotherapy with con- comitant 5-ﬂuorouracil was given to tumor bed and regional lymph nodes up to 40–55.4 Gy. Median duration of follow-up was 31 months (range 6–286) for all patients and 90 months (range 14–286) for survivors. Results CRT (?) group included more patients with advanced nodal stage and overall stage group (p = 0.003 and 0.002, respectively). The 5-year overall survival rates were not different between CRT (-) and CRT (?) groups (50.1 vs. 46.7%, p = 0.794). CRT (?) group achieved a superior 5-year loco-regional relapse-free survival rate compared with CRT (-) group, but the difference did not reach a statistical signiﬁcance (80.1 vs. 68.4%, p =
World Journal of Surgery – Springer Journals
Published: Jun 4, 2018
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