Role of Adjuvant Chemoradiotherapy for Duodenal Cancer: An Updated Analysis of Long-Term Follow-Up from Single Institution

Role of Adjuvant Chemoradiotherapy for Duodenal Cancer: An Updated Analysis of Long-Term... Background There are only limited data on the failure patterns after surgical resection for duodenal cancer, and the role of adjuvant chemoradiotherapy (CRT) also remains controversial. In this study, the treatment outcomes of surgery alone were compared to those of surgery plus adjuvant CRT for duodenal cancer. Methods Between January 1991 and February 2013, a total of 47 patients with duodenal cancer had pancre- aticoduodenectomy, and their age ranged from 31 to 80 (median 62). Twenty-five patients (53%) underwent surgery alone, while 22 (47%) underwent surgery plus adjuvant CRT. Postoperative radiotherapy with con- comitant 5-fluorouracil was given to tumor bed and regional lymph nodes up to 40–55.4 Gy. Median duration of follow-up was 31 months (range 6–286) for all patients and 90 months (range 14–286) for survivors. Results CRT (?) group included more patients with advanced nodal stage and overall stage group (p = 0.003 and 0.002, respectively). The 5-year overall survival rates were not different between CRT (-) and CRT (?) groups (50.1 vs. 46.7%, p = 0.794). CRT (?) group achieved a superior 5-year loco-regional relapse-free survival rate compared with CRT (-) group, but the difference did not reach a statistical significance (80.1 vs. 68.4%, p = http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png World Journal of Surgery Springer Journals

Role of Adjuvant Chemoradiotherapy for Duodenal Cancer: An Updated Analysis of Long-Term Follow-Up from Single Institution

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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Société Internationale de Chirurgie
Subject
Medicine & Public Health; Surgery; Abdominal Surgery; Cardiac Surgery; General Surgery; Thoracic Surgery; Vascular Surgery
ISSN
0364-2313
eISSN
1432-2323
D.O.I.
10.1007/s00268-018-4692-9
Publisher site
See Article on Publisher Site

Abstract

Background There are only limited data on the failure patterns after surgical resection for duodenal cancer, and the role of adjuvant chemoradiotherapy (CRT) also remains controversial. In this study, the treatment outcomes of surgery alone were compared to those of surgery plus adjuvant CRT for duodenal cancer. Methods Between January 1991 and February 2013, a total of 47 patients with duodenal cancer had pancre- aticoduodenectomy, and their age ranged from 31 to 80 (median 62). Twenty-five patients (53%) underwent surgery alone, while 22 (47%) underwent surgery plus adjuvant CRT. Postoperative radiotherapy with con- comitant 5-fluorouracil was given to tumor bed and regional lymph nodes up to 40–55.4 Gy. Median duration of follow-up was 31 months (range 6–286) for all patients and 90 months (range 14–286) for survivors. Results CRT (?) group included more patients with advanced nodal stage and overall stage group (p = 0.003 and 0.002, respectively). The 5-year overall survival rates were not different between CRT (-) and CRT (?) groups (50.1 vs. 46.7%, p = 0.794). CRT (?) group achieved a superior 5-year loco-regional relapse-free survival rate compared with CRT (-) group, but the difference did not reach a statistical significance (80.1 vs. 68.4%, p =

Journal

World Journal of SurgerySpringer Journals

Published: Jun 4, 2018

References

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