J. Membrane Biol. 178, 73–87 (2000) The Journal of DOI: 10.1007/s002320010016 Membrane Biology © Springer-Verlag New York Inc. 2000 Topical Review Role of Actin Cytoskeleton in Regulation of Ion Transport: Examples from Epithelial Cells S. Khurana Johns Hopkins University School of Medicine, G.I. Division, Baltimore MD 21205, USA Received 8 May 2000/Revised: 11 July 2000 Introduction between the external milieu and the organism’s interior. Both the vectorial transport and barrier functions of epi- thelia are dependent on the polarized distribution of pro- “Cytoskeleton-membrane interactions” go far beyond teins and lipids between the apical plasma membrane simple structural or mechanical linkages between the domain and the basolateral domain. The apical mem- cytoskeleton and the plasma membranes and are now brane has a unique protein composition specific to the recognized as dynamic interactions that include newly epithelial cell type and function. The apical membrane recognized functions involving signal transduction path- ways. Results from diverse studies such as signal trans- of epithelial cells is described as “less fluid” than the duction, membrane trafficking, channel and ion transport basolateral membrane due to: (i) a higher cholesterol/ proteins suggest that the cytoskeleton may play a key protein ratio, (ii) a lower phospholipid/protein ratio, (iii)
The Journal of Membrane Biology – Springer Journals
Published: Nov 15, 2000
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