Robust inflammatory and fibrotic signaling following volumetric muscle loss: a barrier to muscle regeneration

Robust inflammatory and fibrotic signaling following volumetric muscle loss: a barrier to muscle... Larouche et al. Cell Death and Disease (2018) 9:409 DOI 10.1038/s41419-018-0455-7 Cell Death & Disease COMMENT Open Access Robust inflammatory and fibrotic signaling following volumetric muscle loss: a barrier to muscle regeneration 1,4 2 3 1 Jacqueline Larouche ,Sarah M. Greising , Benjamin T. Corona and Carlos A. Aguilar Skeletal muscle has a remarkable regenerative capacity, profiling using high-throughput sequencing (RNA- which is conferred by a pool of resident stem cells, known sequencing). Consistent with previous reports, histologi- as satellite cells. After damage, satellite cells proliferate, cal analysis showed progressive fibrosis, macrophage differentiate, and fuse to form new or repair existing infiltration, and minimal muscle fiber regeneration 6, 7 multinucleated myofibers. However, after surgical or throughout the period observed . Using RNA-seq on traumatic loss of a critical mass of muscle, also known as the injured tissues and several types of bioinformatics volumetric muscle loss (VML), this endogenous regen- analyses, the investigators found a series of enriched gene erative competence is overwhelmed. Rather VML has sets associated with chemotaxis and inflammation that been shown to induce robust scar deposition, fibrotic were followed by pathways associated with excessive supplantation, loss of function, and serious morbidity . extracellular matrix (ECM) deposition http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cell Death & Disease Springer Journals

Robust inflammatory and fibrotic signaling following volumetric muscle loss: a barrier to muscle regeneration

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Publisher
Nature Publishing Group UK
Copyright
Copyright © 2018 by The Author(s)
Subject
Life Sciences; Life Sciences, general; Biochemistry, general; Cell Biology; Immunology; Cell Culture; Antibodies
eISSN
2041-4889
D.O.I.
10.1038/s41419-018-0455-7
Publisher site
See Article on Publisher Site

Abstract

Larouche et al. Cell Death and Disease (2018) 9:409 DOI 10.1038/s41419-018-0455-7 Cell Death & Disease COMMENT Open Access Robust inflammatory and fibrotic signaling following volumetric muscle loss: a barrier to muscle regeneration 1,4 2 3 1 Jacqueline Larouche ,Sarah M. Greising , Benjamin T. Corona and Carlos A. Aguilar Skeletal muscle has a remarkable regenerative capacity, profiling using high-throughput sequencing (RNA- which is conferred by a pool of resident stem cells, known sequencing). Consistent with previous reports, histologi- as satellite cells. After damage, satellite cells proliferate, cal analysis showed progressive fibrosis, macrophage differentiate, and fuse to form new or repair existing infiltration, and minimal muscle fiber regeneration 6, 7 multinucleated myofibers. However, after surgical or throughout the period observed . Using RNA-seq on traumatic loss of a critical mass of muscle, also known as the injured tissues and several types of bioinformatics volumetric muscle loss (VML), this endogenous regen- analyses, the investigators found a series of enriched gene erative competence is overwhelmed. Rather VML has sets associated with chemotaxis and inflammation that been shown to induce robust scar deposition, fibrotic were followed by pathways associated with excessive supplantation, loss of function, and serious morbidity . extracellular matrix (ECM) deposition

Journal

Cell Death & DiseaseSpringer Journals

Published: Mar 14, 2018

References

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