Larouche et al. Cell Death and Disease (2018) 9:409 DOI 10.1038/s41419-018-0455-7 Cell Death & Disease COMMENT Open Access Robust inﬂammatory and ﬁbrotic signaling following volumetric muscle loss: a barrier to muscle regeneration 1,4 2 3 1 Jacqueline Larouche ,Sarah M. Greising , Benjamin T. Corona and Carlos A. Aguilar Skeletal muscle has a remarkable regenerative capacity, proﬁling using high-throughput sequencing (RNA- which is conferred by a pool of resident stem cells, known sequencing). Consistent with previous reports, histologi- as satellite cells. After damage, satellite cells proliferate, cal analysis showed progressive ﬁbrosis, macrophage differentiate, and fuse to form new or repair existing inﬁltration, and minimal muscle ﬁber regeneration 6, 7 multinucleated myoﬁbers. However, after surgical or throughout the period observed . Using RNA-seq on traumatic loss of a critical mass of muscle, also known as the injured tissues and several types of bioinformatics volumetric muscle loss (VML), this endogenous regen- analyses, the investigators found a series of enriched gene erative competence is overwhelmed. Rather VML has sets associated with chemotaxis and inﬂammation that been shown to induce robust scar deposition, ﬁbrotic were followed by pathways associated with excessive supplantation, loss of function, and serious morbidity . extracellular matrix (ECM) deposition
Cell Death & Disease – Springer Journals
Published: Mar 14, 2018
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