RIX-4414 Reactions 1680, p300 - 2 Dec 2017 Intussusception: case report In a study, an infant [age and sex not stated] was described, who developed intussusception following treatment with RIX-4414 [monovalent rotavirus vaccine, Rotarix; route, dosage and time to reaction onset not stated]. The infant received RIX-4414 vaccine. The infant developed intussusception following administration of first dose of RIX-4414 vaccine. Despite confirmed intussusception episode after the first dose, the infant was given a second dose. No repeat episode of intussusception was observed after the second dose of the RIX-4414 vaccine. Author comment: "This case was one of 10 infantswho received a second dose despite confirmed intussusceptionepisode after their first dose." "The 2–3 fold elevated risk of intussusception after a first andsecond dose of RV1 demonstrated by our study, would resultin an estimated 21 additional intussusception cases each yearin England." Stowe J, et al. The risk of intussusception following monovalent rotavirus vaccination in England: A self-controlled case-series evaluation. Vaccine 34: 3684-3689, No. 32, 12 Jul 2016. Available from: URL: http://doi.org/10.1016/ j.vaccine.2016.04.050 - United Kingdom 803284730 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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