Reactions 1704, p332 - 2 Jun 2018 Various toxicities: case report A 62-year-old woman developed sedation, dyskinesia of the right upper extremity, hemiballism and akathisia following treatment with risperidone [time to reaction onset not stated; not all outcomes stated]. The woman, who was bed redden for ten months, suddenly walked up to the nursing station. She had been receiving treatment with oral risperidone 0.5mg twice a day as needed, which was prescribed by the previous nursing station to manage her aggression and agitation. The risperidone treatment was stopped a day prior to the event. She had a history of behaviour disturbance, dementia with psychosis, dysphagia and aphasia. The physical examination showed dyskinesia of the right upper extremity, hemiballism, and akathisia. She did not follow commands, was not oriented to person place or time and was unable to speak, but was alert. It was considered that the sedation and the non-ambulatory condition was secondary to the risperidone therapy. Author comment: "Additional side effects include mild sedation, EEG abnormalities, orthostatic hypotension, EPS, tardive dyskinesia". "Risperidone increases in concentration, at higher doses, in an age-dependent manner, and has a half-life of 20 to 22 hours; this may partially explain why the patient experienced sedation, but started walking shortly after discontinuing the medication." Lwanga A, et al. "She can walk". Miracles happen when we de-prescribe. Journal of the American Geriatrics Society 66 (Suppl. 2): S16 abstr. A13, Apr 2018. Available from: URL: http://doi.org/10.1111/jgs.15376 [abstract] - USA 803323473 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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