Risk of fatal motor vehicle collisions in zolpidem users

Risk of fatal motor vehicle collisions in zolpidem users Reactions 1704, p12 - 2 Jun 2018 Risk of fatal motor vehicle collisions in zolpidem users A prescription for zolpidem on the previous day is associated with an increased risk of motor vehicle collisions (MVCs), according to the results of a study in South Korea reported in Drug Safety, indicating that "more education for healthcare professionals and patients who drive is needed". The case-crossover study included drivers who died of MVCs in 2010–2014 and who received a prescription for zolpidem during the preceding year. The one-day case period prior to the MVC was compared with 4 earlier one-day control periods, 90 days apart. Of the 7061 included drivers, with a mean age of 61.6 years, 714 patients had prescriptions for zolpidem. The zolpidem prescription frequency was 105 (14.8%) during the case period and 354 (12.4%) during the control periods. In conditional regression analysis, after adjustment for time-varying exposure to confounding medications, zolpidem was associated with an increased risk of fatal MVCs (odds ratio [OR] 1.48; 95% CI 1.06, 2.07). The risk was significantly increased for new zolpidem users (OR 2.37; 1.40, 4.00), but not for patients with a record of prescriptions for zolpidem 1 year prior to the study period. The MVC risk was increased in patients with a Charlson Comorbidity Index score ≥5 (OR 1.81; 1.16, 2.84), which the authors note "might be associated with drug interactions of zolpidem". The risk was also increased in patients <65 years of age (OR 1.62; 1.03, 2.56). The absence of an association in older drivers "may be explained by their driving patterns," note the authors, or their "relatively long driving experience". Yang BR, et al. Prescription of Zolpidem and the Risk of Fatal Motor Vehicle Collisions: A Population-Based, Case-Crossover Study from South Korea. CNS Drugs : 23 May 2018. Available from: URL: https://doi.org/10.1007/ s40263-018-0520-x 803323900 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Risk of fatal motor vehicle collisions in zolpidem users

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46655-7
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p12 - 2 Jun 2018 Risk of fatal motor vehicle collisions in zolpidem users A prescription for zolpidem on the previous day is associated with an increased risk of motor vehicle collisions (MVCs), according to the results of a study in South Korea reported in Drug Safety, indicating that "more education for healthcare professionals and patients who drive is needed". The case-crossover study included drivers who died of MVCs in 2010–2014 and who received a prescription for zolpidem during the preceding year. The one-day case period prior to the MVC was compared with 4 earlier one-day control periods, 90 days apart. Of the 7061 included drivers, with a mean age of 61.6 years, 714 patients had prescriptions for zolpidem. The zolpidem prescription frequency was 105 (14.8%) during the case period and 354 (12.4%) during the control periods. In conditional regression analysis, after adjustment for time-varying exposure to confounding medications, zolpidem was associated with an increased risk of fatal MVCs (odds ratio [OR] 1.48; 95% CI 1.06, 2.07). The risk was significantly increased for new zolpidem users (OR 2.37; 1.40, 4.00), but not for patients with a record of prescriptions for zolpidem 1 year prior to the study period. The MVC risk was increased in patients with a Charlson Comorbidity Index score ≥5 (OR 1.81; 1.16, 2.84), which the authors note "might be associated with drug interactions of zolpidem". The risk was also increased in patients <65 years of age (OR 1.62; 1.03, 2.56). The absence of an association in older drivers "may be explained by their driving patterns," note the authors, or their "relatively long driving experience". Yang BR, et al. Prescription of Zolpidem and the Risk of Fatal Motor Vehicle Collisions: A Population-Based, Case-Crossover Study from South Korea. CNS Drugs : 23 May 2018. Available from: URL: https://doi.org/10.1007/ s40263-018-0520-x 803323900 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

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