Eur J Plast Surg (2016) 39:335–344 DOI 10.1007/s00238-016-1196-4 ORIGINAL PAPER 1 1 1 Sanjib Tripathee & Jue Zhang & Meng Xiong Received: 12 January 2016 /Accepted: 19 April 2016 /Published online: 28 May 2016 Springer-Verlag Berlin Heidelberg 2016 Abstract severe nausea/vomiting (OR = 1.16; 95 % CI = 0.66, 2.04, Background The pathogenesis of microtia is still unclear. P = 0.61); NSAIDs during pregnancy (OR = 1.17, 95 % Various risk factors have been studied but they remain incon- CI = 0.61,2.22, P = 0.64); antihypertensives during pregnancy clusive. We conducted the first ever systematic review and (OR = 1.84,95 % CI = 0.94,3.62, P = 0.08); and illegal drugs meta-analysis to look for the association between microtia during pregnancy (OR = 1.69; 95 % CI = 0.65, 4.39, P=0.28). and various environmental risk factors. Reduced risk for microtia was found with these factors: folic Methods Relevant case-control studies published between acid (OR = 0.55; 95 % CI = 0.33, 0.92, P = 0.02); advanced January 2000 to October 2014 were identified through a sys- maternal age (OR = 0.94; 95 % CI = 0.79, 1.11, P=0.45); am- tematic search in PubMed and EMBASE. Reference lists from picillin during
European Journal of Plastic Surgery – Springer Journals
Published: May 28, 2016
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