Rifaximin Reactions 1680, p297 - 2 Dec 2017 Abdominal pain, vomiting and discolouration of teeth: 3 case reports In a retrospective observational study (IMPRESS) of 207 patients, 3 patients [ages and sexes not stated] were described, who developed abdominal pain, vomiting or discolouration of teeth during treatment with rifaximin [rifaximin-α; routes, dosages and duration of treatments to reactions onset not stated]. The patients, who had hepatic encephalopathy (HE), received treatment with rifaximin. Subsequently, the patients developed abdominal pain (1 patient), vomiting (1 patient) and showed discolouration of teeth (1 patient) [outcomes not stated]. Author comment: "Nine patients (4%) had documented [adverse events]: Clostridium difficile infection (n=4), rash (n=2), abdominal pain, vomiting and discolouration of teeth (one patient each)." "The low number of [adverse events] and C difficile cases in our study demonstrates good tolerability and is consistent with both the clinical trials of rifaximin-α and previous [United Kingdom] audits." Hudson M, et al. The impact of rifaximin-alpha on the hospital resource use associated with the management of patients with hepatic encephalopathy: A retrospective observational study (IMPRESS). Frontline Gastroenterology 8: 243-251, No. 4, 1 Oct 2017. Available from: URL: http://doi.org/10.1136/ flgastro-2016-100792 - United Kingdom 803285005 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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