Eur J Nutr (2018) 57:219–230 https://doi.org/10.1007/s00394-016-1311-0 ORIGINAL CONTRIBUTION Rice bran protein hydrolysates reduce arterial stiffening, vascular remodeling and oxidative stress in rats fed a high‑carbohydrate and high‑fat diet 1 1 1 Ketmanee Senaphan · Weerapon Sangartit · Poungrat Pakdeechote · 2 2 Veerapol Kukongviriyapan · Patchareewan Pannangpetch · 3 4 1 Supawan Thawornchinsombut · Stephen E. Greenwald · Upa Kukongviriyapan Received: 27 April 2016 / Accepted: 2 September 2016 / Published online: 22 September 2016 © Springer-Verlag Berlin Heidelberg 2016 Abstract necrosis factor-alpha in plasma. Oxidative stress was also Purpose Rice bran protein hydrolysates (RBPH) contain alleviated after RBPH treatment by decreasing plasma highly nutritional proteins and antioxidant compounds malondialdehyde, reducing superoxide production and sup- phox which show benefits against metabolic syndrome (MetS). pressing p47 NADPH oxidase expression in the vascu- Increased arterial stiffness and the components of MetS lar tissues of HCHF rats. RBPH increased plasma nitrate/ have been shown to be associated with an increased risk nitrite level and up-regulated eNOS expression in the aortas of cardiovascular disease. This study aimed to investigate of HCHF-diet-fed rats, indicating that RBPH increased NO whether RBPH could alleviate the metabolic disorders, production. arterial stiffening, vascular remodeling, and oxidative stress Conclusion
European Journal of Nutrition – Springer Journals
Published: Sep 22, 2016
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