Leukemia (2018) 32:1477–1478 https://doi.org/10.1038/s41375-018-0105-1 COMMENT Acute myeloid leukemia 1 2 Florian Kuchenbauer Christian Buske Received: 20 February 2018 / Accepted: 23 February 2018 / Published online: 23 March 2018 © Macmillan Publishers Limited, part of Springer Nature 2018 Acute promyelocytic leukemia (APL), which accounts for and the underlying molecular mechanisms of thrombocy- 10–15% of acute myeloid leukemia (AML) cases, is one of topenia, caused by APL cells are not fully understood. the true success stories in oncology, as targeted therapeutic In this issue of Leukemia, Lavallée et al.  reported approaches have converted this former lethal disease into a on intriguing ﬁndings, characterizing Podoplanin (PDPN), a disease from which the vast majority of patients is cured. gene involved in platelet aggregation, as a protein speciﬁ- Historically, this unique and highly lethal leukemia subtype cally expressed in human APL and being able to cause was characterized by fatal bleeding events as documented thrombocytopenia and prolonged bleeding time in a xeno- by early studies in the 1950s with median survival rates graft model of human AML cell lines. often below 1 month . This progress in the clinical How did they identify PDPN as a key gene in APL? management of
Leukemia – Springer Journals
Published: Mar 23, 2018
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