Mammalian Genome 10, 1041–1042 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis 1 1 3 1,2 1,2 William K. Decker, Karla R. Bowles, Edward C. Schatte, Jeffrey A. Towbin, William J. Craigen Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA Department of Urology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA Received: 21 April 1999 / Accepted: 26 May 1999 Voltage-dependent anion channels (VDACs) are 30 kDa, pore- consistent with that of the mouse (Sampson et al. 1997). All intron/ forming proteins found in the outer mitochondrial membranes of exon splice junctions follow the consensus AG-GT rule and con- eukaryotic organisms (reviewed by Sorgato and Moran 1993). The form to established exon boundary sequences (Shapiro and Sen- mammalian VDAC gene family consists of three isoforms, each apathy 1987). approximately 70% identical to the other two family members. The Genebridge4 radiation hybrid mapping panel was used to While it has been postulated that VDACs play a role in
Mammalian Genome – Springer Journals
Published: Oct 1, 1999
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