Review and Comparison of the Long Acting Methylphenidate Preparations

Review and Comparison of the Long Acting Methylphenidate Preparations The stimulants have been the mainstay of pharmacologic treatment for over fifty years. Methylphenidate is the most frequently prescribed of the stimulant agents. In the past, one of the main drawbacks of these agents was the abbreviated duration of action. Over the last few years three longer acting methylphenidate preparations have been released to the market. Though all these agents contain the same chemical compound they do vary in a number of ways. In this article we will present how the formulations compare in their technology and the differences in their delivery systems. We will also compare the available literature that focus on head to head comparisons in terms of pharmacokinetics studies and those reports that present efficacy data. Finally, we will suggest based on a theoretical framework on how to approach selecting an agent based on the results of these trials and the individual needs of the patient. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychiatric Quarterly Springer Journals

Review and Comparison of the Long Acting Methylphenidate Preparations

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2005 by Springer Science + Business Media, Inc.
Subject
Medicine & Public Health; Psychiatry; Public Health; Sociology, general
ISSN
0033-2720
eISSN
1573-6709
D.O.I.
10.1007/s11126-005-2979-0
Publisher site
See Article on Publisher Site

Abstract

The stimulants have been the mainstay of pharmacologic treatment for over fifty years. Methylphenidate is the most frequently prescribed of the stimulant agents. In the past, one of the main drawbacks of these agents was the abbreviated duration of action. Over the last few years three longer acting methylphenidate preparations have been released to the market. Though all these agents contain the same chemical compound they do vary in a number of ways. In this article we will present how the formulations compare in their technology and the differences in their delivery systems. We will also compare the available literature that focus on head to head comparisons in terms of pharmacokinetics studies and those reports that present efficacy data. Finally, we will suggest based on a theoretical framework on how to approach selecting an agent based on the results of these trials and the individual needs of the patient.

Journal

Psychiatric QuarterlySpringer Journals

Published: Jan 1, 2005

References

  • Attention deficit disorder and hyperkinetic disorder
    Swanson, JM; Seargent, JA; Taylor, E
  • Attention deficit hyperactivity disorder: Advances in cognitive, neurobiological, and genetic research
    Tannock, R
  • Advances in the pharmacotherapy of attention-deficit hyperactivity disorder: Focus on methylphenidate formulations
    Markowitz, JS; Straughn, AB; Patrick, KS

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