Digestive Diseases and Sciences (2018) 63:547–548 https://doi.org/10.1007/s10620-017-4872-8 EDITORIAL Revenge of the NERDs: Cadherin Fragments Differentiate Functional Heartburn from Non‑erosive Reflux Disease 1,2 1,2 Carlo Calabrese · Marco Salice Published online: 12 January 2018 © Springer Science+Business Media, LLC, part of Springer Nature 2018 To the Editor, likely the result of biased studies that included patients with non-GERD-related upper gastrointestinal symptoms . Due to the ever-increasing use of proton pump inhibitors Twenty-four-hour esophageal pH monitoring is useful (PPI), the therapeutic front line in gastroesophageal reflux to define the etiology of heartburn symptoms. Recently, disease (GERD) has changed. The successful healing of the addition of impedance, which recognizes fluid reflux, esophagitis, an elusive therapeutic target a mere 25 years along with pH monitoring has enhanced the ability to detect ago, has been eclipsed by new considerations, with emphasis patients with FH . Nevertheless, these techniques have now being focused on symptom resolution, in particular, some intrinsic limitations: (a) esophageal acid exposure heartburn. Moreover, patients with heartburn are a hetero- time presents a physiological day-to-day variability due geneous group, including subpopulations with different to variations of dietary habits and physical activity; (b) mechanisms responsible for their symptoms. Patients with symptoms reported during single-day monitoring are often GERD symptoms
Digestive Diseases and Sciences – Springer Journals
Published: Jan 12, 2018
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