Results of experimental implantation of microvascular prostheses in three recipient animal species

Results of experimental implantation of microvascular prostheses in three recipient animal species A total of 286 knitted vascular prostheses made of polyethylene terephthalate and surface-treated with polyurethane, polylactide, or both were implanted over the past 6 years. Of this total number, 224 prostheses were implanted in rats, nine in dogs, and 53 in pigs. We developed 39 types of knitted prostheses. The best results were obtained with prosthesis no. 36, which was surface-treated with polyurethane and polylactide. Prostheses 10 mm in length with a diameter of 2 mm implanted into rat aortas showed 100% patency during the observation periods of 2 months (ten implants) and 1 year (40 implants). Although various antithrombotic treatment schemes were tested, implantations of 5-cm- to 10-cm-long no. 36 prostheses in dogs were unsuccessful. The results of implantation of 3-mm caliber no. 36 prostheses to pigs were comparable with those obtained with Gore-Tex prostheses. Intensive antithrombotic treatment with heparin and Rheomacrodex intraoperatively followed by Fraxiparine (0.3 ml/12 h), was necessary to ensure early patency of the implants. Lower dosage of antithrombotic drugs resulted in transient incomplete occlusion of the implant. Full patency resumed after 1 month. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

Results of experimental implantation of microvascular prostheses in three recipient animal species

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Publisher
Springer Journals
Copyright
Copyright © 2002 by Springer-Verlag
Subject
Medicine & Public Health; Plastic Surgery
ISSN
0930-343X
eISSN
1435-0130
D.O.I.
10.1007/s00238-002-0380-x
Publisher site
See Article on Publisher Site

Abstract

A total of 286 knitted vascular prostheses made of polyethylene terephthalate and surface-treated with polyurethane, polylactide, or both were implanted over the past 6 years. Of this total number, 224 prostheses were implanted in rats, nine in dogs, and 53 in pigs. We developed 39 types of knitted prostheses. The best results were obtained with prosthesis no. 36, which was surface-treated with polyurethane and polylactide. Prostheses 10 mm in length with a diameter of 2 mm implanted into rat aortas showed 100% patency during the observation periods of 2 months (ten implants) and 1 year (40 implants). Although various antithrombotic treatment schemes were tested, implantations of 5-cm- to 10-cm-long no. 36 prostheses in dogs were unsuccessful. The results of implantation of 3-mm caliber no. 36 prostheses to pigs were comparable with those obtained with Gore-Tex prostheses. Intensive antithrombotic treatment with heparin and Rheomacrodex intraoperatively followed by Fraxiparine (0.3 ml/12 h), was necessary to ensure early patency of the implants. Lower dosage of antithrombotic drugs resulted in transient incomplete occlusion of the implant. Full patency resumed after 1 month.

Journal

European Journal of Plastic SurgerySpringer Journals

Published: Sep 22, 2002

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