Response to “What Do Aquaporin Knockout Studies Tell Us about Fluid Transport in Epithelia?” Maclaren OJ, Sneyd J, Crampin EJ (2013) J Membr Biol 246:297–305

Response to “What Do Aquaporin Knockout Studies Tell Us about Fluid Transport in Epithelia?”... J Membrane Biol (2013) 246:665–667 DOI 10.1007/s00232-013-9585-0 LETTE R T O T HE EDI T OR Response to ‘‘What Do Aquaporin Knockout Studies Tell Us about Fluid Transport in Epithelia?’’ Maclaren OJ, Sneyd J, Crampin EJ (2013) J Membr Biol 246:297–305 A. E. Hill Y. Shachar-Hill Received: 31 July 2013 / Accepted: 4 August 2013 / Published online: 22 August 2013 Springer Science+Business Media New York 2013 Dear Sir, untrue; and (3) that their claim that a basis for this effect Epithelial isotonic fluid transport was originally assumed to can be found in a recent article of theirs in this journal be based upon osmotic equilibration following active salt (Maclaren et al. 2012) is unsupported. transport, and with the discovery of aquaporins (AQPs) The authors repeatedly comment on our failure to real- present in epithelial membranes and dominating the osmotic ize the ‘‘nonlinearity’’ of the problem, meaning that we permeability, it became apparent that genetic knockout (KO) assume a reduction in osmotic permeability should be of these would be a specific test of the osmotic theory. Such reflected in a proportional reduction in fluid flow; we do experiments were conducted for several AQPs in water not, but linearity had http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Response to “What Do Aquaporin Knockout Studies Tell Us about Fluid Transport in Epithelia?” Maclaren OJ, Sneyd J, Crampin EJ (2013) J Membr Biol 246:297–305

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Publisher
Springer Journals
Copyright
Copyright © 2013 by Springer Science+Business Media New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s00232-013-9585-0
Publisher site
See Article on Publisher Site

Abstract

J Membrane Biol (2013) 246:665–667 DOI 10.1007/s00232-013-9585-0 LETTE R T O T HE EDI T OR Response to ‘‘What Do Aquaporin Knockout Studies Tell Us about Fluid Transport in Epithelia?’’ Maclaren OJ, Sneyd J, Crampin EJ (2013) J Membr Biol 246:297–305 A. E. Hill Y. Shachar-Hill Received: 31 July 2013 / Accepted: 4 August 2013 / Published online: 22 August 2013 Springer Science+Business Media New York 2013 Dear Sir, untrue; and (3) that their claim that a basis for this effect Epithelial isotonic fluid transport was originally assumed to can be found in a recent article of theirs in this journal be based upon osmotic equilibration following active salt (Maclaren et al. 2012) is unsupported. transport, and with the discovery of aquaporins (AQPs) The authors repeatedly comment on our failure to real- present in epithelial membranes and dominating the osmotic ize the ‘‘nonlinearity’’ of the problem, meaning that we permeability, it became apparent that genetic knockout (KO) assume a reduction in osmotic permeability should be of these would be a specific test of the osmotic theory. Such reflected in a proportional reduction in fluid flow; we do experiments were conducted for several AQPs in water not, but linearity had

Journal

The Journal of Membrane BiologySpringer Journals

Published: Aug 22, 2013

References

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