Response Letter

Response Letter Breast Cancer Res Treat (2017) 165:469–470 DOI 10.1007/s10549-017-4352-z REBUTTAL LETTER Gail Lewis Phillips Received: 27 May 2017 / Accepted: 19 June 2017 / Published online: 30 June 2017 Springer Science+Business Media, LLC 2017 Dear Breast Cancer Research and Treatment Editors: brain microenvironment as a resistance mechanism to PI3K inhibitors in experimental brain lesions. Interestingly, it On behalf of my co-authors, we would like to thank Drs. was also demonstrated that Neuregulins, a family of HER3 Askoxylakis, Kodack, Ferraro, and Jain for their com- ligands, could desensitize tumor cells to PI3K inhibition, mentary on our recently published paper ‘‘Trastuzumab and this was reversed by co-treatment with a HER3 anti- Uptake and its Relation to Efficacy in an Animal Model of body or with pertuzumab, a HER2-HER3 dimerization HER2-Positive Breast Cancer Brain Metastasis (Breast inhibitor. The findings in this manuscript provide addi- Cancer Res Treat DOI: 10.1007/s10549-017-4279-4)’’. tional support for our hypothesis of differences in Briefly, our findings demonstrated uptake of labeled tras- microenvironment influencing response to targeted ther- tuzumab in intracranial brain grafts that was equivalent to apy, and confirm, in different mouse tumor models, our uptake in orthotopic (mammary fat pad, MFP) tumors, yet data showing enhanced efficacy with Breast Cancer Research and Treatment Springer Journals

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Medicine & Public Health; Oncology
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