RESEARCH AND DEVELOPMENT OF SOLIDAGO
CAUCASICA HERBAL DRY EXTRACT
V. V. Fedotova
and D. A. Konovalov
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 3, pp. 28 – 31, March, 2018.
Original article submitted April 19, 2016.
The preparation of Solidago caucasica herbal dry extract from the plant was studied by us for the first time.
The main quality indicator was a flavonoid content of ³ 2.5%. Other biologically active compounds, e.g.,
coumarins, phenolic carboxylic acids, and organic acids, were also present.
Keywords: Solidago caucasica, dry extract, flavonoids, diuretic effect, antibacterial activity.
Solidago caucasica Kem.-Nath. (Asteraceae) is indige-
nous to the Caucasus. Preparations based on raw material of
several Solidago spp. (S. virgaurea, S. canadensis, S. gigan-
tea) are used in domestic and global pharmaceutical practice
to prevent and treat inflammations of the urinary tract, pros-
tatitis, urolithiasis, and other diseases . The pharmaco-
gnosy of poorly studied representatives of this genus as
sources of new medicinal plant raw material (MPR) and
pharmacologically active compounds remains a promising
direction with respect to expanding the variety of domestic
MPR for medical use and solving problems of import-substi
tution and new efficacious drug development.
Flavonoids, coumarins, phenolic carboxylic acids , or
ganic acids , amino acids , triterpenes , carbohy
drates , and macro- and microelements  were detected
and identified by us for the first time in S. caucasica herb.
Solidago caucasica herbal dry extract was prepared us
ing maceration, which was the simplest and most compact
method and is widely used in industry. Preliminary investiga
tions found that EtOH (50%) gave the greatest yield of ex
tracted compounds. Therefore, it was chosen as the extrac
Solidago caucasica herb was collected in the Daut River
gorge up to Uchkulan Pass (Karachay District, Karachay-
Cherkessia Republic) at the start of flowering by cutting off
the upper part of the stems (25 – 30 cm).
Raw material was ground to particle size £ 7 mm, loaded
into a maceration tank, and treated with EtOH (50%, 1:10 ra
tio). The extraction used fractional maceration (in four
stages). The total extract was filtered into a vacuum-evapora
tor flask through three layers of cheesecloth. The resulting
extract was condensed by evaporation at 50 – 60°C and re
duced pressure (600 – 500 mm) to a suitable thickness. The
thick extract was placed into a vacuum drying cabinet and
dried to residual moisture £ 5% (at 60 – 65°C) . The dry
extract was ground in a ball mill, packed hermetically into
polyethylene bags, and stored in a dark place at 15 – 25°C
according to the SP XIIIth Ed. . The yield of final product
recalculated as air-dried raw material was 24.94 ± 0.52%.
RESULTS AND DISCUSSION
The obtained Solidago caucasica herbal dry extract en
abled studies of the indicators according to which it should
Description. Dark-brown powder, specific aromatic
Pharmaceutical Chemistry Journal, Vol. 52, No. 3, June, 2018 (Russian Original Vol. 52, No. 3, March, 2018)
0091-150X/18/5203-0216 © 2018 Springer Science+Business Media, LLC
Pyatigorsk Medico-Pharmaceutical Institute, Branch of Volgograd State
Medical University, RF Ministry of Health, 11 Prosp. Kalinina,
Pyatigorsk, Stavropol Krai, 357532 Russia.