96 Letters to the Editor used for the plots; lacking such, they suggest a very Bertl is not right when he comments that ‘‘. . . patch- strong bias in data acquisition or selection, thus throwing clamp experiments were learned by explicit instructions into question all other results presented. in my laboratory’’ since we have already published two papers (Ramirez, Vacata, McCusker, Haber, Mortimer, A somewhat different — albeit equally worrisome Owen and Lecar: Proc. Natl. Acad. Sci. USA 86:1989, point — is that the large capacitive currents in Fig. 8D 7866–7870, and Vacata, Ho¨fer, Larsson and Lecar: J. and E, again uncommented by the authors, indicate Bioenerg. Biomembr. 24, 1993, 43–53) using patch- severe technical problems with either data acquisi- clamp techniques on yeast protoplasts. tion or processing and open to doubt all point plots The points of criticism by Dr. Bertl are mostly emo- which are not directly supported by displayed current tional and polemical. To avoid endless argumentation traces. we prefer not to answer each point in detail. Instead, we Thus, this paper is deeply flawed in its failure to would like to emphasize some facts that may help to acknowledge my substantial contribution to the
The Journal of Membrane Biology – Springer Journals
Published: Feb 4, 2014
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