Eur Arch Otorhinolaryngol (2017) 274:3543–3544 DOI 10.1007/s00405-017-4499-6 LETTER TO THE EDITOR Reply to the letter to the editor concerning: “The therapeutic effect of thymoquinone on acoustic trauma-induced hearing loss in rats” 1 1 1 Ozlem Celebi Erdivanli · Mahmut Ogurlu · Engin Dursun Received: 30 January 2017 / Accepted: 31 January 2017 / Published online: 14 March 2017 © Springer-Verlag Berlin Heidelberg 2017 Dear Editor, study dose (20 mg/kg) with the double dose (40 mg/kg), which is lower than the first quartile considering Al-Ali’s Thank you for the opportunity to reply to the letter of study. The possibility of TQ toxicity was mentioned in the Aksoy et al. to our paper “The therapeutic effect of thymo- discussion section of our paper, referring to AbuKhader’s quinone on acoustic trauma-induced hearing loss in rats”. paper. However, unpublished data of our pilot experiments We would like to thank the authors of the first study with i.p. TQ do not support AbuKhader’s findings. We suc- reporting the reparative effect of the thymoquinone (TQ) cessfully administered i.p. doses up to 40 mg/kg, without in acoustic trauma induced hearing loss for their comments noticing any side effect such as peritonitis or weight loss. . We apologize for the misrepresentation about Aksoy Our study was not powered
European Archives of Oto-Rhino-Laryngology – Springer Journals
Published: Mar 14, 2017
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