Arch Toxicol (2017) 91:3191–3193 DOI 10.1007/s00204-017-2025-7 LETTER TO THE EDITOR, NEWS AND VIEWS Reply to the Commentary by Lotti M. and Moretto A. “Organophosphate neurotoxicity to the voluntary motor system on the trail of environment‑caused amyotrophic lateral sclerosis: the known, the misknown and the unknown 1,2,3 1,2,3 1,2,3,4 1,2,3 Samantha J. Merwin · Teresa Obis · Yanelli Nunez · Diane B. Re Received: 20 June 2017 / Accepted: 28 June 2017 / Published online: 12 July 2017 © Springer-Verlag GmbH Germany 2017 Keywords Organophosphate · Delayed neuropathy · Moretto. We chose the term OPIDN for several reasons. Neurotoxicity · Motor neuron · Amyotrophic lateral First, we share with others the opinion that OPIDN is more sclerosis · Neurodegeneration appropriate than OPIDP, as “polyneuropathy” classically refers to damages or disorders affecting only the peripheral nerves, for discussion, see (Khurana et al. 2000; Vasconcel- We thank Drs. Lotti and Moretto for their commentary that los et al. 2002). Although peripheral insult initially predom- indicates where we may have further clarified the intended inates, the consensus is that OPIDN usually progressively messages in our review article (Merwin et al. 2017). This involves the pyramidal tract, i.e., central lesions (Gutmann reply gives us
Archives of Toxicology – Springer Journals
Published: Jul 12, 2017
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