Reply 72 Letters to the Editor normal ATPase activity (e.g. [7]). The changes in pH this skeptically. Although it may appear more complex and  are sufficient to explain the drug resistance to some, the altered partitioning model for Pgp is actually [5, 6]. Along with other work (e.g. [7]) it is quite clear much simpler, does not violate fundamental laws of bi- at this point that Pgp overexpression causes changes in ology and chemistry as does the drug pump model [1], pH and  that can easily explain drug resistance and can conceivably explain the vast majority of pub- caused by Pgp alone. These data argue strongly for al- lished observations made with unadulterated systems. ternate “indirect” models. Various aspects of these mod- The same cannot be said for various pump models. els actually have a rich history (e.g. [4, 8]) that is also neglected by Sharom. Sincerely, There are other omissions. It is stated “Pgp ATPase Paul D. Roepe, Ph.D. activity can be further stimulated by the addition of... Department of Chemistry & Lombardi Cancer Center drugs...” It is not stated that this is also true for other Georgetown University ATPases, none of which have ever been hypothesized The Journal of Membrane Biology Springer Journals

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Copyright © 1998 by Springer-Verlag New York Inc.
Life Sciences; Biochemistry, general; Human Physiology
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