Curr Pediatr Rep (2017) 5:87–99 DOI 10.1007/s40124-017-0138-3 RENAL (R PAREKH, SECTION EDITOR) 1,2 1,2 1,2 Sally Kellett & Natasha Jawa & Damien Noone Published online: 15 June 2017 Springer Science + Business Media New York 2017 Abstract Introduction Purpose of Review Renal vasculitis in children, while rare, can be life threatening and associated with significant morbid- Vasculitis is characterized by a systemic inflammation of ity and mortality. Although sometimes renal limited, more blood vessels that leads to tissue damage and resultant end often, the kidney is affected as part of a more systemic disor- organ failure from either ischemia or hemorrhage. Vasculitis der. While there are increasing numbers of pediatric case se- can be idiopathic, autoimmune, or secondary to infections or ries, management decisions are derived from randomized con- drugs . Depending on the disease or size of the blood ves- trolled trials conducted in adults. The aim of this review is to sels involved, there may be residual damage to the blood ves- summarize the recent literature on the pathogenesis, manage- sels in the form of stenosis or aneurysms. The clinical presen- ment, and outcome of small-, medium-, and large-vessel renal tation of these systemic vasculitides is often
Current Pediatrics Reports – Springer Journals
Published: Jun 15, 2017
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