J. Membrane Biol. 158, 95–107 (1997) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1997 Topical Review Renal Transporters for Organic Anions and Organic Cations. Structural Requirements for Substrates K.J. Ullrich Max-Planck-Institut fu ¨ r Biophysik, Frankfurt am Main, Kennedyallee 70, Germany Received: 15 January 1997/Revised: 16 April 1997 Introduction Na -sulfate cotransport system, rheogenic, cloned, eight putative transmembrane segments . 4. The contralu- minal sulfate/oxalate exchange system, not potential sen- Recently multisubstrate specificity became popular sitive, cloned, twelve putative transmembrane segments through studies of multidrug resistance in tumor cells . 5. The luminal Na /dicarboxylate cotransport sys-  and bacteria . The phenomenon of multisub- tem, rheogenic, cloned, eight putative transmembrane strate specificity, however, was recognized long ago in segments . 6. The contraluminal Na /dicarboxylate studies of the transport of organic anions and organic cotransport system, rheogenic, clone not yet identified. cations in the kidney [11, 21, 48, 83] and the liver . Cation transporters: 1. Contraluminal organic cation Actually all xenobiotics (chemicals and drugs), which transport system, the main transport system for the se- are taken up by animals are finally excreted by these cretion of organic cations, exchange possible, faculta- organs, either directly
The Journal of Membrane Biology – Springer Journals
Published: Jul 15, 1997
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