Renal Transporters for Organic Anions and Organic Cations. Structural Requirements for Substrates

Renal Transporters for Organic Anions and Organic Cations. Structural Requirements for Substrates J. Membrane Biol. 158, 95–107 (1997) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1997 Topical Review Renal Transporters for Organic Anions and Organic Cations. Structural Requirements for Substrates K.J. Ullrich Max-Planck-Institut fu ¨ r Biophysik, Frankfurt am Main, Kennedyallee 70, Germany Received: 15 January 1997/Revised: 16 April 1997 Introduction Na -sulfate cotransport system, rheogenic, cloned, eight putative transmembrane segments [27]. 4. The contralu- minal sulfate/oxalate exchange system, not potential sen- Recently multisubstrate specificity became popular sitive, cloned, twelve putative transmembrane segments through studies of multidrug resistance in tumor cells [28]. 5. The luminal Na /dicarboxylate cotransport sys- [16] and bacteria [43]. The phenomenon of multisub- tem, rheogenic, cloned, eight putative transmembrane strate specificity, however, was recognized long ago in segments [34]. 6. The contraluminal Na /dicarboxylate studies of the transport of organic anions and organic cotransport system, rheogenic, clone not yet identified. cations in the kidney [11, 21, 48, 83] and the liver [36]. Cation transporters: 1. Contraluminal organic cation Actually all xenobiotics (chemicals and drugs), which transport system, the main transport system for the se- are taken up by animals are finally excreted by these cretion of organic cations, exchange possible, faculta- organs, either directly http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Renal Transporters for Organic Anions and Organic Cations. Structural Requirements for Substrates

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Publisher
Springer-Verlag
Copyright
Copyright © Inc. by 1997 Springer-Verlag New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s002329900247
Publisher site
See Article on Publisher Site

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