original article Wien Klin Wochenschr (2018) 130:436–445 https://doi.org/10.1007/s00508-018-1350-z Long-term effects of anticoagulation and over-anticoagulation with warfarin Yigi ˘ t Çanga · Tolga Sinan Güvenç · Ali Nazmi Çalık · Mehmet Baran Karatas¸ · Evliya Akdeniz · Gizem Yüksel · Ayse ¸ Emre Received: 27 January 2018 / Accepted: 15 May 2018 / Published online: 4 June 2018 © Springer-Verlag GmbH Austria, part of Springer Nature 2018 Summary the duration of warfarin use (p < 0.001) and the inter- Background Warfarin-related nephropathy (WRN) is action between the duration of warfarin use and TATR a complication of warfarin over-anticoagulation that (p = 0.03). Similar ﬁndings were observed in patients is associated with acute and/or chronic renal dysfunc- without CKD at baseline, but not in those with CKD tion and increased mortality. The long-term effects of before the index operation. warfarin on renal function has not been adequately Conclusion Anticoagulation over targeted INR values studied in patients with a mechanical prosthetic valve is associated with a steeper decline in eGFR and an (MPV). increased frequency of CKD in patients with a MPV. Aim To study the time-dependent effects of over-anti- coagulation on renal function in patients with a MPV. Keywords Warfarin ·
Wiener klinische Wochenschrift – Springer Journals
Published: Jun 4, 2018
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