Access the full text.
Sign up today, get DeepDyve free for 14 days.
E. Norgett, S. Hatsell, L. Carvajal-Huerta, Juan-Carlos Cabezas, J. Common, P. Purkis, N. Whittock, I. Leigh, H. Stevens, D. Kelsell (2000)
Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma.Human molecular genetics, 9 18
Maralice Conacci-Sorrell, J. Zhurinsky, A. Ben-Ze'ev (2002)
The cadherin-catenin adhesion system in signaling and cancer.The Journal of clinical investigation, 109 8
L. Carvajal-Huerta (1998)
Epidermolytic palmoplantar keratoderma with woolly hair and dilated cardiomyopathy.Journal of the American Academy of Dermatology, 39 3
J. Gard, Kiyomi Yamada, K. Green, B. Eloff, D. Rosenbaum, Xuejun Wang, J. Robbins, R. Schuessler, Kathryn Yamada, J. Saffitz (2005)
Remodeling of gap junctions and slow conduction in a mouse model of desmin-related cardiomyopathy.Cardiovascular research, 67 3
Jianping Zhuang, Kathryn Yamada, J. Saffitz, A. Kleber (2000)
Pulsatile Stretch Remodels Cell-to-Cell Communication in Cultured MyocytesCirculation Research: Journal of the American Heart Association, 87
S. Kaplan, J. Gard, L. Carvajal-Huerta, J. Ruiz-Cabezas, G. Thiene, J. Saffitz (2004)
Structural and molecular pathology of the heart in Carvajal syndrome.Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 13 1
Kiyomi Yamada, K. Green, A. Samarel, J. Saffitz (2005)
Distinct Pathways Regulate Expression of Cardiac Electrical and Mechanical Junction Proteins in Response to StretchCirculation Research, 97
J. Saffitz, D. Lerner, Kathryn Yamada (2004)
Chapter 21 – Gap Junction Distribution and Regulation in the Heart
B. Eloff, D. Lerner, Kathryn Yamada, R. Schuessler, J. Saffitz, David Rosenbaum (2001)
High resolution optical mapping reveals conduction slowing in connexin43 deficient mice.Cardiovascular research, 51 4
Suma Thomas, R. Schuessler, C. Berul, M. Beardslee, E. Beyer, M. Mendelsohn, J. Saffitz (1998)
Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction: evidence for chamber-specific molecular determinants of conduction.Circulation, 97 7
D. Zipes, J. Jalife (1990)
Cardiac Electrophysiology: From Cell to Bedside
S Kanno, A Kovacs, KA Yamada, JE Saffitz (2003)
Connexin43 as a determinant of infarct size following coronary occlusion in miceJ Am Coll Cardiol, 41
S. Kanno, A. Kovács, Kathryn Yamada, J. Saffitz (2003)
Connexin43 as a determinant of myocardial infarct size following coronary occlusion in mice.Journal of the American College of Cardiology, 41 4
N. Protonotarios, A. Tsatsopoulou (2004)
Naxos disease and Carvajal syndrome: cardiocutaneous disorders that highlight the pathogenesis and broaden the spectrum of arrhythmogenic right ventricular cardiomyopathy.Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 13 4
Rhea Pimentel, Kathryn Yamada, A. Kleber, J. Saffitz (2002)
Autocrine Regulation of Myocyte Cx43 Expression by VEGFCirculation Research: Journal of the American Heart Association, 90
Xuejun Wang, H. Osińska, G. Dorn, M. Nieman, J. Lorenz, A. Gerdes, S. Witt, T. Kimball, J. Gulick, J. Robbins (2001)
Mouse Model of Desmin-Related CardiomyopathyCirculation: Journal of the American Heart Association, 103
S. Kaplan, J. Gard, N. Protonotarios, A. Tsatsopoulou, C. Spiliopoulou, A. Anastasakis, C. Squarcioni, W. McKenna, G. Thiene, C. Basso, N. Brousse, G. Fontaine, J. Saffitz (2004)
Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease).Heart rhythm, 1 1
N. Protonotarios, A. Tsatsopoulou, K. Gatzoulis (2002)
Arrhythmogenic right ventricular cardiomyopathy caused by a deletion in plakoglobin (Naxos disease).Cardiac electrophysiology review, 6 1-2
G. Mckoy, N. Protonotarios, A. Crosby, A. Tsatsopoulou, A. Anastasakis, A. Coonar, M. Norman, C. Baboonian, S. Jeffery, W. McKenna (2000)
Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease)The Lancet, 355
D. Lerner, Kathryn Yamada, R. Schuessler, J. Saffitz (2000)
Accelerated onset and increased incidence of ventricular arrhythmias induced by ischemia in Cx43-deficient mice.Circulation, 101 5
RC Pimentel, KA Yamada, AG Kléber, JE Saffitz (2002)
Autocrine regulation of Cx43 expression by VEGFCirc Res, 90
J. Saffitz (2005)
Dependence of Electrical Coupling on Mechanical Coupling in Cardiac Myocytes: Insights Gained from Cardiomyopathies Caused by Defects in Cell‐Cell ConnectionsAnnals of the New York Academy of Sciences, 1047
N. Narin, M. Akçakuş, T. Gunes, A. Baykan, K. Uzum, Ayten Ferahbaş (2003)
Arrhythmogenic Right Ventricular Cardiomyopathy (Naxos Disease):Pacing and Clinical Electrophysiology, 26
N. Protonotarios, A. Tsatsopoulou, A. Anastasakis, E. Sevdalis, Godfrina McKoy, Kostas Stratos, Kostas Gatzoulis, Kostas Tentolouris, C. Spiliopoulou, Demos Panagiotakos, William Mckenna, P. Toutouzas (2001)
Genotype-phenotype assessment in autosomal recessive arrhythmogenic right ventricular cardiomyopathy (Naxos disease) caused by a deletion in plakoglobin.Journal of the American College of Cardiology, 38 5
Electrical activation of the myocardium to produce effective pumping of blood depends on the orderly coordinated spatial and temporal transfer of current from one cell to another via gap junctions. Normal ventricular myocytes are extensively coupled by gap junctions and have the capacity to rapidly increase the amount of connexin within gap junction plaques to meet physiological demands for enhanced cell-cell communication. However, myocytes can also rapidly uncouple in response to injury or disease. In general, both acute and chronic forms of heart disease caused by diverse etiologies are associated with changes in the expression of connexins and remodeling of gap junctions. Such remodeling may have both adaptive and maladaptive consequences and contribute to major clinical processes such as heart failure and sudden cardiac death. Our laboratory has investigated mechanisms regulating cell-cell electrical coupling in the heart under physiological and pathophysiological conditions. This review is focused on selected aspects of this work pertaining to changes in coupling in response to acute and chronic ischemic heart disease and in familial cardiomyopathies caused by mutations in genes encoding desmosomal proteins.
The Journal of Membrane Biology – Springer Journals
Published: Jun 22, 2007
Access the full text.
Sign up today, get DeepDyve free for 14 days.