Release Testing of Selected Drugs from Surface Magnetic Nanoparticles and Their Diffusion Through a Membrane

Release Testing of Selected Drugs from Surface Magnetic Nanoparticles and Their Diffusion Through... In this study, magnetic nanoparticles were functionalized with dextran and immobilized ibuprofen, diclofenac, and dopamine in order to investigate the diffusion of drugs through a dialysis membrane under biological conditions such as a temperature of 37.0°C and pH 7.4. The concentration of released drugs was measured both inside the membrane and upon release into solution using spectrofluorimetric and spectrophotometric methods. The mechanism of drug release from the carrier was analyzed in terms of the Korsmeyer – Peppas model. The results show that differences in the mechanism of drug release depend on the time-diffusion process and the type of drug used. In addition, the atomic force microscopy and confocal microscopy methods were used to investigate the interaction between bacterial cells and functionalized nanoparticles. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmaceutical Chemistry Journal Springer Journals

Release Testing of Selected Drugs from Surface Magnetic Nanoparticles and Their Diffusion Through a Membrane

Loading next page...
 
/lp/springer_journal/release-testing-of-selected-drugs-from-surface-magnetic-nanoparticles-in44P86vgp
Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Pharmacy; Pharmacy; Pharmacology/Toxicology; Organic Chemistry
ISSN
0091-150X
eISSN
1573-9031
D.O.I.
10.1007/s11094-018-1803-8
Publisher site
See Article on Publisher Site

Abstract

In this study, magnetic nanoparticles were functionalized with dextran and immobilized ibuprofen, diclofenac, and dopamine in order to investigate the diffusion of drugs through a dialysis membrane under biological conditions such as a temperature of 37.0°C and pH 7.4. The concentration of released drugs was measured both inside the membrane and upon release into solution using spectrofluorimetric and spectrophotometric methods. The mechanism of drug release from the carrier was analyzed in terms of the Korsmeyer – Peppas model. The results show that differences in the mechanism of drug release depend on the time-diffusion process and the type of drug used. In addition, the atomic force microscopy and confocal microscopy methods were used to investigate the interaction between bacterial cells and functionalized nanoparticles.

Journal

Pharmaceutical Chemistry JournalSpringer Journals

Published: Jun 2, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off