Magn Reson Mater Phy (2018) 31:425–438 https://doi.org/10.1007/s10334-017-0660-x RESEARCH ARTICLE Relative enhanced diffusivity: noise sensitivity, protocol optimization, and the relation to intravoxel incoherent motion 1 2,3,4 5 4 1,5 Peter T. While · Jose R. Teruel · Igor Vidić · Tone F. Bathen · Pål Erik Goa Received: 17 May 2017 / Revised: 17 October 2017 / Accepted: 19 October 2017 / Published online: 6 November 2017 © ESMRMB 2017 Abstract maximizing its discriminatory power. RED was shown to be Objective To explore the relationship between rela- essentially a reparameterization of the IVIM estimates for f tive enhanced diffusivity (RED) and intravoxel incoher - and D obtained with three b values. ent motion (IVIM), as well as the impact of noise and the Conclusion RED imaging in the breast and liver should choice of intermediate diffusion weighting ( b value) on the be performed with intermediate b values of 100 and 50 s/ RED parameter. mm , respectively. Future clinical studies involving RED Materials and methods A mathematical derivation was should also estimate the IVIM parameters f and D using performed to cast RED in terms of the IVIM parameters. three b values for comparison. Noise analysis and b value optimization was conducted by using Monte Carlo calculations to generate diffusion- Keywords Diffusion-weighted MRI · Cancer screening · weighted imaging
Magnetic Resonance Materials in Physics, Biology and Medicine – Springer Journals
Published: Nov 6, 2017
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