Relationships in Dissolution and Solvation of Miconazole Nitrate in Binary and Ternary Solvents Based on Polyethylene Glycol-400

Relationships in Dissolution and Solvation of Miconazole Nitrate in Binary and Ternary Solvents... The solubility of 1-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazole nitrate (miconazole nitrate) C1 8H1 4Cl4N2O · HNO3 in binary mixtures 1,2-propylene glycol-polyethelene glycol-400 and in ternary mixtures of these glycols with water at 293.15 K was studied. The correlation between the miconazole nitrate solubility and the dielectric constant of the solvents was discussed. The deviations of the miconazole nitrate solubility from additivity throughout the composition range of mixed solvents were calculated. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Applied Chemistry Springer Journals

Relationships in Dissolution and Solvation of Miconazole Nitrate in Binary and Ternary Solvents Based on Polyethylene Glycol-400

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2002 by MAIK “Nauka/Interperiodica”
Subject
Chemistry; Chemistry/Food Science, general
ISSN
1070-4272
eISSN
1608-3296
D.O.I.
10.1023/A:1023379113339
Publisher site
See Article on Publisher Site

Abstract

The solubility of 1-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazole nitrate (miconazole nitrate) C1 8H1 4Cl4N2O · HNO3 in binary mixtures 1,2-propylene glycol-polyethelene glycol-400 and in ternary mixtures of these glycols with water at 293.15 K was studied. The correlation between the miconazole nitrate solubility and the dielectric constant of the solvents was discussed. The deviations of the miconazole nitrate solubility from additivity throughout the composition range of mixed solvents were calculated.

Journal

Russian Journal of Applied ChemistrySpringer Journals

Published: Oct 13, 2004

References

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