The solubility of 1-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazole nitrate (miconazole nitrate) C1 8H1 4Cl4N2O · HNO3 in binary mixtures 1,2-propylene glycol-polyethelene glycol-400 and in ternary mixtures of these glycols with water at 293.15 K was studied. The correlation between the miconazole nitrate solubility and the dielectric constant of the solvents was discussed. The deviations of the miconazole nitrate solubility from additivity throughout the composition range of mixed solvents were calculated.
Russian Journal of Applied Chemistry – Springer Journals
Published: Oct 13, 2004
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