Relationships between markers of inflammation and bone density: findings from the Hertfordshire Cohort Study

Relationships between markers of inflammation and bone density: findings from the Hertfordshire... Summary Among 365 Hertfordshire Cohort Study participants (aged 59–71 years at baseline), higher adiponectin and adiponectin to leptin ratios were associated with lower baseline lumbar spine and femoral neck bone mineral density (BMD). Lower IL-10 was associated with accelerated decline in lumbar spine BMD. This suggests that bone health can be influenced by changes in immune phenotype and alterations in adipokine homeostasis. Introduction The aim of this study was to examine the association between indices of inflammation and BMD in a population- based cohort of older adults in the UK. Methods Analyses were based on a sample of 194 men and 171 women of the Hertfordshire Cohort Study (community-living, older adults). Dual energy X-ray absorptiometry (DXA) was performed at the lumbar spine and proximal femur at baseline and repeated at a median of 4.5 years (inter-quartile range 3.6 to 5.2). Inflammatory markers (CRP, TNF, IL-1β, IL-6, IL-8, IL-10, adiponectin and leptin) were ascertained at baseline using enzyme-linked immunosorbent assay (ELISA) techniques and Bio- Plex Pro Assays. Gender-adjusted linear regression was used to examine the associations between markers of inflammation and outcomes with and without adjustment for anthropometric and lifestyle factors. Results The mean (SD) ages at baseline were 64.4 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Osteoporosis International Springer Journals

Relationships between markers of inflammation and bone density: findings from the Hertfordshire Cohort Study

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Publisher
Springer Journals
Copyright
Copyright © 2018 by International Osteoporosis Foundation and National Osteoporosis Foundation
Subject
Medicine & Public Health; Orthopedics; Endocrinology; Rheumatology
ISSN
0937-941X
eISSN
1433-2965
DOI
10.1007/s00198-018-4503-z
Publisher site
See Article on Publisher Site

Abstract

Summary Among 365 Hertfordshire Cohort Study participants (aged 59–71 years at baseline), higher adiponectin and adiponectin to leptin ratios were associated with lower baseline lumbar spine and femoral neck bone mineral density (BMD). Lower IL-10 was associated with accelerated decline in lumbar spine BMD. This suggests that bone health can be influenced by changes in immune phenotype and alterations in adipokine homeostasis. Introduction The aim of this study was to examine the association between indices of inflammation and BMD in a population- based cohort of older adults in the UK. Methods Analyses were based on a sample of 194 men and 171 women of the Hertfordshire Cohort Study (community-living, older adults). Dual energy X-ray absorptiometry (DXA) was performed at the lumbar spine and proximal femur at baseline and repeated at a median of 4.5 years (inter-quartile range 3.6 to 5.2). Inflammatory markers (CRP, TNF, IL-1β, IL-6, IL-8, IL-10, adiponectin and leptin) were ascertained at baseline using enzyme-linked immunosorbent assay (ELISA) techniques and Bio- Plex Pro Assays. Gender-adjusted linear regression was used to examine the associations between markers of inflammation and outcomes with and without adjustment for anthropometric and lifestyle factors. Results The mean (SD) ages at baseline were 64.4

Journal

Osteoporosis International – Springer Journals

Published: May 28, 2018

References

  • Osteoporosis: impact on health and economics
    Harvey, N; Dennison, E; Cooper, C
  • Measuring the musculoskeletal aging phenotype
    Dawson, A; Dennison, E
  • Interpretation and use of FRAX in clinical practice
    Kanis, JA; Hans, D; Cooper, C; Baim, S; Bilezikian, JP; Binkley, N; Cauley, JA; Compston, JE; Dawson-Hughes, B; El-Hajj Fuleihan, G; Johansson, H; Leslie, WD; Lewiecki, EM; Luckey, M; Oden, A; Papapoulos, SE; Poiana, C; Rizzoli, R; Wahl, DA; McCloskey, EV
  • Osteoclast differentiation and activation
    Boyle, WJ; Simonet, WS; Lacey, DL
  • C-reactive protein predicts incident fracture in community-dwelling elderly Japanese women: the Muramatsu study
    Nakamura, K; Saito, T; Kobayashi, R; Oshiki, R; Oyama, M; Nishiwaki, T; Nashimoto, M; Tsuchiya, Y
  • Inflammatory markers and the risk of hip and vertebral fractures in men: the osteoporotic fractures in men (MrOS)
    Cauley, JA; Barbour, KE; Harrison, SL; Cloonan, YK; Danielson, ME; Ensrud, KE; Fink, HA; Orwoll, ES; Boudreau, R
  • High-sensitivity C-reactive protein and risk of nontraumatic fractures in the Bruneck study
    Schett, G; Kiechl, S; Weger, S; Pederiva, A; Mayr, A; Petrangeli, M; Oberhollenzer, F; Lorenzini, R; Redlich, K; Axmann, R; Zwerina, J; Willeit, J
  • High-sensitivity C-reactive protein and fracture risk in elderly women
    Pasco, JA; Kotowicz, MA; Henry, MJ; Nicholson, GC; Spilsbury, HJ; Box, JD; Schneider, HG
  • Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study
    Cauley, JA; Danielson, ME; Boudreau, RM; Forrest, KY; Zmuda, JM; Pahor, M; Tylavsky, FA; Cummings, SR; Harris, TB; Newman, AB
  • C-reactive protein, bone strength, and nine-year fracture risk: data from the Study of Women’s Health Across the Nation (SWAN)
    Ishii, S; Cauley, JA; Greendale, GA; Crandall, CJ; Danielson, ME; Ouchi, Y; Karlamangla, AS
  • High-sensitivity C-reactive protein is an independent risk factor for non-vertebral fractures in women and men: the Tromso Study
    Dahl, K; Ahmed, LA; Joakimsen, RM; Jorgensen, L; Eggen, AE; Eriksen, EF; Bjornerem, A
  • Inflammatory markers and the risk of hip fracture: the Women’s Health Initiative
    Barbour, KE; Boudreau, R; Danielson, ME; Youk, AO; Wactawski-Wende, J; Greep, NC; LaCroix, AZ; Jackson, RD; Wallace, RB; Bauer, DC; Allison, MA; Cauley, JA
  • Inflammatory markers and risk of hip fracture in older white women: the study of osteoporotic fractures
    Barbour, KE; Lui, LY; Ensrud, KE; Hillier, TA; LeBlanc, ES; Ing, SW; Hochberg, MC; Cauley, JA
  • Relationship of C-reactive protein and bone mineral density in community-dwelling elderly females
    Ganesan, K; Teklehaimanot, S; Tran, TH; Asuncion, M; Norris, K
  • Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis
    Koh, JM; Khang, YH; Jung, CH; Bae, S; Kim, DJ; Chung, YE; Kim, GS
  • Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study
    Ding, C; Parameswaran, V; Udayan, R; Burgess, J; Jones, G
  • Associations of TNF-alpha and IL-6 polymorphisms with osteoporosis through joint effects and interactions with LEPR gene in Taiwan: Taichung Community Health Study for Elders (TCHS-E)
    Lin, CC; Li, TC; Liu, CS; Yang, CW; Lin, CH; Hsiao, JH; Meng, NH; Lin, WY; Liao, LN; Li, CI; Wu, FY
  • Serum interleukin 6 is a major predictor of bone loss in women specific to the first decade past menopause
    Scheidt-Nave, C; Bismar, H; Leidig-Bruckner, G; Woitge, H; Seibel, MJ; Ziegler, R; Pfeilschifter, J
  • Relationship between serum inflammatory marker and bone mineral density in healthy adults
    Lim, HS; Park, YH; Kim, SK
  • Adipokines and the risk of fracture in older adults
    Barbour, KE; Zmuda, JM; Boudreau, R; Strotmeyer, ES; Horwitz, MJ; Evans, RW; Kanaya, AM; Harris, TB; Bauer, DC; Cauley, JA
  • A cross-sectional study of the association between adipokine levels and bone mineral density according to obesity and menopausal status in Korean women
    Haam, JH; Kim, YS; Kim, MJ; Koo, HS; Kim, HY; Kim, HJ; Park, KH; Joo, NS; Park, KC
  • The effects of adiponectin and leptin on changes in bone mineral density
    Barbour, KE; Zmuda, JM; Boudreau, R; Strotmeyer, ES; Horwitz, MJ; Evans, RW; Kanaya, AM; Harris, TB; Cauley, JA
  • Adipocytokines: mediators linking adipose tissue, inflammation and immunity
    Tilg, H; Moschen, AR
  • Role of adipokines signaling in the modulation of T cells function
    Procaccini, C; Rosa, V; Galgani, M; Carbone, F; Rocca, C; Formisano, L; Matarese, G
  • Associations among endocrine, inflammatory, and bone markers, body composition and weight loss induced bone loss
    Labouesse, MA; Gertz, ER; Piccolo, BD; Souza, EC; Schuster, GU; Witbracht, MG; Woodhouse, LR; Adams, SH; Keim, NL; Loan, MD
  • Cohort profile: the Hertfordshire cohort study
    Syddall, H; Sayer, AA; Dennison, E; Martin, H; Barker, D; Cooper, C
  • Levels of customary physical activity among the old and the very old living at home
    Dallosso, HM; Morgan, K; Bassey, EJ; Ebrahim, SB; Fentem, PH; Arie, TH
  • Current patterns of diet in community-dwelling older men and women: results from the Hertfordshire Cohort Study
    Robinson, S; Syddall, H; Jameson, K; Batelaan, S; Martin, H; Dennison, EM; Cooper, C; Sayer, AA
  • Symptoms of anxiety or depression and risk of fracture in older people: the Hertfordshire Cohort Study
    Gale, CR; Dennison, EM; Edwards, M; Sayer, AA; Cooper, C
  • Extent of regression dilution for established and novel coronary risk factors: results from the British Regional Heart Study
    Emberson, JR; Whincup, PH; Morris, RW; Walker, M; Lowe, GD; Rumley, A
  • High serum adiponectin predicts incident fractures in elderly men: osteoporotic fractures in men (MrOS) Sweden
    Johansson, H; Oden, A; Lerner, UH; Jutberger, H; Lorentzon, M; Barrett-Connor, E; Karlsson, MK; Ljunggren, O; Smith, U; McCloskey, E; Kanis, JA; Ohlsson, C; Mellstrom, D
  • Inflammaging and ‘Garb-aging’
    Franceschi, C; Garagnani, P; Vitale, G; Capri, M; Salvioli, S
  • Inflamm-aging. An evolutionary perspective on immunosenescence
    Franceschi, C; Bonafe, M; Valensin, S; Olivieri, F; Luca, M; Ottaviani, E; Benedictis, G
  • Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians
    Gerli, R; Monti, D; Bistoni, O; Mazzone, AM; Peri, G; Cossarizza, A; Gioacchino, M; Cesarotti, ME; Doni, A; Mantovani, A; Franceschi, C; Paganelli, R
  • Postoperative prevention of falls in older adults with fragility fractures
    Demontiero, O; Gunawardene, P; Duque, G
  • Increased fat mass is associated with increased bone size but reduced volumetric density in pre pubertal children
    Cole, ZA; Harvey, NC; Kim, M; Ntani, G; Robinson, SM; Inskip, HM; Godfrey, KM; Cooper, C; Dennison, EM
  • Spontaneous release of interleukin 1 from human blood monocytes reflects bone formation in idiopathic osteoporosis
    Pacifici, R; Rifas, L; Teitelbaum, S; Slatopolsky, E; McCracken, R; Bergfeld, M; Lee, W; Avioli, LV; Peck, WA
  • Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokines
    Nakashima, T; Kobayashi, Y; Yamasaki, S; Kawakami, A; Eguchi, K; Sasaki, H; Sakai, H
  • IL-1beta inhibits human osteoblast migration
    Hengartner, NE; Fiedler, J; Ignatius, A; Brenner, RE
  • Interleukin 10-deficient mice develop osteopenia, decreased bone formation, and mechanical fragility of long bones
    Dresner-Pollak, R; Gelb, N; Rachmilewitz, D; Karmeli, F; Weinreb, M
  • Association of interleukin 10 haplotype with low bone mineral density in Korean postmenopausal women
    Park, BL; Han, IK; Lee, HS; Kim, LH; Kim, SJ; Shin, JS; Kim, SY; Shin, HD
  • Circulating levels of IL-6 and TNF-alpha are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults
    Stannus, O; Jones, G; Cicuttini, F; Parameswaran, V; Quinn, S; Burgess, J; Ding, C

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