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Abstract
Summary Among 365 Hertfordshire Cohort Study participants (aged 59–71 years at baseline), higher adiponectin and adiponectin to leptin ratios were associated with lower baseline lumbar spine and femoral neck bone mineral density (BMD). Lower IL-10 was associated with accelerated decline in lumbar spine BMD. This suggests that bone health can be influenced by changes in immune phenotype and alterations in adipokine homeostasis. Introduction The aim of this study was to examine the association between indices of inflammation and BMD in a population- based cohort of older adults in the UK. Methods Analyses were based on a sample of 194 men and 171 women of the Hertfordshire Cohort Study (community-living, older adults). Dual energy X-ray absorptiometry (DXA) was performed at the lumbar spine and proximal femur at baseline and repeated at a median of 4.5 years (inter-quartile range 3.6 to 5.2). Inflammatory markers (CRP, TNF, IL-1β, IL-6, IL-8, IL-10, adiponectin and leptin) were ascertained at baseline using enzyme-linked immunosorbent assay (ELISA) techniques and Bio- Plex Pro Assays. Gender-adjusted linear regression was used to examine the associations between markers of inflammation and outcomes with and without adjustment for anthropometric and lifestyle factors. Results The mean (SD) ages at baseline were 64.4
Journal
Osteoporosis International – Springer Journals
Published: May 28, 2018
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References
-
Osteoporosis: impact on health and economicsHarvey, N; Dennison, E; Cooper, C
-
Measuring the musculoskeletal aging phenotypeDawson, A; Dennison, E
-
Interpretation and use of FRAX in clinical practiceKanis, JA; Hans, D; Cooper, C; Baim, S; Bilezikian, JP; Binkley, N; Cauley, JA; Compston, JE; Dawson-Hughes, B; El-Hajj Fuleihan, G; Johansson, H; Leslie, WD; Lewiecki, EM; Luckey, M; Oden, A; Papapoulos, SE; Poiana, C; Rizzoli, R; Wahl, DA; McCloskey, EV
-
Osteoclast differentiation and activationBoyle, WJ; Simonet, WS; Lacey, DL
-
C-reactive protein predicts incident fracture in community-dwelling elderly Japanese women: the Muramatsu studyNakamura, K; Saito, T; Kobayashi, R; Oshiki, R; Oyama, M; Nishiwaki, T; Nashimoto, M; Tsuchiya, Y
-
Inflammatory markers and the risk of hip and vertebral fractures in men: the osteoporotic fractures in men (MrOS)Cauley, JA; Barbour, KE; Harrison, SL; Cloonan, YK; Danielson, ME; Ensrud, KE; Fink, HA; Orwoll, ES; Boudreau, R
-
High-sensitivity C-reactive protein and risk of nontraumatic fractures in the Bruneck studySchett, G; Kiechl, S; Weger, S; Pederiva, A; Mayr, A; Petrangeli, M; Oberhollenzer, F; Lorenzini, R; Redlich, K; Axmann, R; Zwerina, J; Willeit, J
-
High-sensitivity C-reactive protein and fracture risk in elderly womenPasco, JA; Kotowicz, MA; Henry, MJ; Nicholson, GC; Spilsbury, HJ; Box, JD; Schneider, HG
-
Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition StudyCauley, JA; Danielson, ME; Boudreau, RM; Forrest, KY; Zmuda, JM; Pahor, M; Tylavsky, FA; Cummings, SR; Harris, TB; Newman, AB
-
C-reactive protein, bone strength, and nine-year fracture risk: data from the Study of Women’s Health Across the Nation (SWAN)Ishii, S; Cauley, JA; Greendale, GA; Crandall, CJ; Danielson, ME; Ouchi, Y; Karlamangla, AS
-
High-sensitivity C-reactive protein is an independent risk factor for non-vertebral fractures in women and men: the Tromso StudyDahl, K; Ahmed, LA; Joakimsen, RM; Jorgensen, L; Eggen, AE; Eriksen, EF; Bjornerem, A
-
Inflammatory markers and the risk of hip fracture: the Women’s Health InitiativeBarbour, KE; Boudreau, R; Danielson, ME; Youk, AO; Wactawski-Wende, J; Greep, NC; LaCroix, AZ; Jackson, RD; Wallace, RB; Bauer, DC; Allison, MA; Cauley, JA
-
Inflammatory markers and risk of hip fracture in older white women: the study of osteoporotic fracturesBarbour, KE; Lui, LY; Ensrud, KE; Hillier, TA; LeBlanc, ES; Ing, SW; Hochberg, MC; Cauley, JA
-
Relationship of C-reactive protein and bone mineral density in community-dwelling elderly femalesGanesan, K; Teklehaimanot, S; Tran, TH; Asuncion, M; Norris, K
-
Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosisKoh, JM; Khang, YH; Jung, CH; Bae, S; Kim, DJ; Chung, YE; Kim, GS
-
Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal studyDing, C; Parameswaran, V; Udayan, R; Burgess, J; Jones, G
-
Associations of TNF-alpha and IL-6 polymorphisms with osteoporosis through joint effects and interactions with LEPR gene in Taiwan: Taichung Community Health Study for Elders (TCHS-E)Lin, CC; Li, TC; Liu, CS; Yang, CW; Lin, CH; Hsiao, JH; Meng, NH; Lin, WY; Liao, LN; Li, CI; Wu, FY
-
Serum interleukin 6 is a major predictor of bone loss in women specific to the first decade past menopauseScheidt-Nave, C; Bismar, H; Leidig-Bruckner, G; Woitge, H; Seibel, MJ; Ziegler, R; Pfeilschifter, J
-
Relationship between serum inflammatory marker and bone mineral density in healthy adultsLim, HS; Park, YH; Kim, SK
-
Adipokines and the risk of fracture in older adultsBarbour, KE; Zmuda, JM; Boudreau, R; Strotmeyer, ES; Horwitz, MJ; Evans, RW; Kanaya, AM; Harris, TB; Bauer, DC; Cauley, JA
-
A cross-sectional study of the association between adipokine levels and bone mineral density according to obesity and menopausal status in Korean womenHaam, JH; Kim, YS; Kim, MJ; Koo, HS; Kim, HY; Kim, HJ; Park, KH; Joo, NS; Park, KC
-
The effects of adiponectin and leptin on changes in bone mineral densityBarbour, KE; Zmuda, JM; Boudreau, R; Strotmeyer, ES; Horwitz, MJ; Evans, RW; Kanaya, AM; Harris, TB; Cauley, JA
-
Adipocytokines: mediators linking adipose tissue, inflammation and immunityTilg, H; Moschen, AR
-
Role of adipokines signaling in the modulation of T cells functionProcaccini, C; Rosa, V; Galgani, M; Carbone, F; Rocca, C; Formisano, L; Matarese, G
-
Associations among endocrine, inflammatory, and bone markers, body composition and weight loss induced bone lossLabouesse, MA; Gertz, ER; Piccolo, BD; Souza, EC; Schuster, GU; Witbracht, MG; Woodhouse, LR; Adams, SH; Keim, NL; Loan, MD
-
Cohort profile: the Hertfordshire cohort studySyddall, H; Sayer, AA; Dennison, E; Martin, H; Barker, D; Cooper, C
-
Levels of customary physical activity among the old and the very old living at homeDallosso, HM; Morgan, K; Bassey, EJ; Ebrahim, SB; Fentem, PH; Arie, TH
-
Current patterns of diet in community-dwelling older men and women: results from the Hertfordshire Cohort StudyRobinson, S; Syddall, H; Jameson, K; Batelaan, S; Martin, H; Dennison, EM; Cooper, C; Sayer, AA
-
Symptoms of anxiety or depression and risk of fracture in older people: the Hertfordshire Cohort StudyGale, CR; Dennison, EM; Edwards, M; Sayer, AA; Cooper, C
-
Extent of regression dilution for established and novel coronary risk factors: results from the British Regional Heart StudyEmberson, JR; Whincup, PH; Morris, RW; Walker, M; Lowe, GD; Rumley, A
-
High serum adiponectin predicts incident fractures in elderly men: osteoporotic fractures in men (MrOS) SwedenJohansson, H; Oden, A; Lerner, UH; Jutberger, H; Lorentzon, M; Barrett-Connor, E; Karlsson, MK; Ljunggren, O; Smith, U; McCloskey, E; Kanis, JA; Ohlsson, C; Mellstrom, D
-
Inflammaging and ‘Garb-aging’Franceschi, C; Garagnani, P; Vitale, G; Capri, M; Salvioli, S
-
Inflamm-aging. An evolutionary perspective on immunosenescenceFranceschi, C; Bonafe, M; Valensin, S; Olivieri, F; Luca, M; Ottaviani, E; Benedictis, G
-
Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenariansGerli, R; Monti, D; Bistoni, O; Mazzone, AM; Peri, G; Cossarizza, A; Gioacchino, M; Cesarotti, ME; Doni, A; Mantovani, A; Franceschi, C; Paganelli, R
-
Postoperative prevention of falls in older adults with fragility fracturesDemontiero, O; Gunawardene, P; Duque, G
-
Increased fat mass is associated with increased bone size but reduced volumetric density in pre pubertal childrenCole, ZA; Harvey, NC; Kim, M; Ntani, G; Robinson, SM; Inskip, HM; Godfrey, KM; Cooper, C; Dennison, EM
-
Spontaneous release of interleukin 1 from human blood monocytes reflects bone formation in idiopathic osteoporosisPacifici, R; Rifas, L; Teitelbaum, S; Slatopolsky, E; McCracken, R; Bergfeld, M; Lee, W; Avioli, LV; Peck, WA
-
Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokinesNakashima, T; Kobayashi, Y; Yamasaki, S; Kawakami, A; Eguchi, K; Sasaki, H; Sakai, H
-
IL-1beta inhibits human osteoblast migrationHengartner, NE; Fiedler, J; Ignatius, A; Brenner, RE
-
Interleukin 10-deficient mice develop osteopenia, decreased bone formation, and mechanical fragility of long bonesDresner-Pollak, R; Gelb, N; Rachmilewitz, D; Karmeli, F; Weinreb, M
-
Association of interleukin 10 haplotype with low bone mineral density in Korean postmenopausal womenPark, BL; Han, IK; Lee, HS; Kim, LH; Kim, SJ; Shin, JS; Kim, SY; Shin, HD
-
Circulating levels of IL-6 and TNF-alpha are associated with knee radiographic osteoarthritis and knee cartilage loss in older adultsStannus, O; Jones, G; Cicuttini, F; Parameswaran, V; Quinn, S; Burgess, J; Ding, C
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