Purpose The purpose of this study was to investigate the ed to LSFG-measured MBR was reasonable, considering the relationship between laser speckle flowgraphy (LSFG) and vascular anatomy of the eye. Thus, PRI, like MBR, may be a optical coherence tomography angiography (OCTA) measure- promising biomarker of ocular microcirculation that can ments of ocular microcirculation in normal and open-angle reveal the presence of ocular diseases such as OAG. glaucoma (OAG) subjects. Methods This study included 18 eyes of 18 OAG patients and Keywords Optical coherence tomography Peripapillary . . ten eyes of ten age-matched healthy controls. LSFG was used retina Angiography Laser speckle flowgraphy to measure mean blur rate (MBR) in the optic nerve head (ONH) vessel area (MV) and tissue area (MT). OCTA was used to measure a new parameter, peripapillary relative inten- Introduction sity (PRI), in the superficial retina, superficial choroid, and deep choroid. Statistical associations were then determined. Glaucoma, a disease characterized by the progressive death of Results MV, MT, superficial-retinal PRI, and superficial- the retinal ganglion cells (RGCs), can cause severe visual choroidal PRI were lower in the OAG subjects than the disturbance. Recently, it has become an increasingly common controls (P =0.02, P <0.001, P
Graefe's Archive for Clinical and Experimental Ophthalmology – Springer Journals
Published: May 1, 2017
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