Relationship between heterozygosity and quantitative traits:intralocus interactions and multiple-locus averaging

Relationship between heterozygosity and quantitative traits:intralocus interactions and... The dependence of the expression of genotypic values (Y) on gene dosage (X) have been analyzed for four types of intralocus interactions (additivity, dominance, overdominance, and neutrality) using a linear model. Artificial numerical examples have been used to demonstrate that X and Y are positively associated with each other in the cases of additivity, dominance, and overdominance and are not associated in the case of neutrality. The averaging of single-locus genotypic values to obtain multiple-locus genotypes yields different results for different types of intralocus interactions. Genotypic values and individual heterozygosity are positively correlated with each other in the cases of dominance and overdominance and are negatively correlated in the case of additivity. In the case of neutrality, there is still no correlation after averaging. The results obtained and their interpretation suggest a new view on the experimental studies and generalizations on the relationship between heterozygosity and quantitative traits. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Relationship between heterozygosity and quantitative traits:intralocus interactions and multiple-locus averaging

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Publisher
Springer Journals
Copyright
Copyright © 2005 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics; Microbial Genetics and Genomics; Animal Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1007/PL00022115
Publisher site
See Article on Publisher Site

Abstract

The dependence of the expression of genotypic values (Y) on gene dosage (X) have been analyzed for four types of intralocus interactions (additivity, dominance, overdominance, and neutrality) using a linear model. Artificial numerical examples have been used to demonstrate that X and Y are positively associated with each other in the cases of additivity, dominance, and overdominance and are not associated in the case of neutrality. The averaging of single-locus genotypic values to obtain multiple-locus genotypes yields different results for different types of intralocus interactions. Genotypic values and individual heterozygosity are positively correlated with each other in the cases of dominance and overdominance and are negatively correlated in the case of additivity. In the case of neutrality, there is still no correlation after averaging. The results obtained and their interpretation suggest a new view on the experimental studies and generalizations on the relationship between heterozygosity and quantitative traits.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Feb 24, 2005

References

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