Purpose: To assess a novel radiotracer aluminum [ F]fluoride-1,4,7-triazacyclononane-triacetic 18 18 acid-pegylated dimeric RGD ([ F]ALF-NOTA-PRGD , denoted as [ F]Alfatide) for positron emission tomography (PET)/X-ray computed tomography (CT) and explore the relationships between clinicopathological characteristics and maximum standard uptake values in primary (SUV ) and metastatic lymph nodes (SUV ) of patients with esophageal squamous cell P LN carcinoma (ESCC), as verified by pathologic examination and compared with those obtained 18 18 with 2-deoxy-2-[ F]fluoro-D-glucose ([ F]DG) PET. Procedures: We prospectively enrolled patients with newly diagnosed ESCC who agreed to 18 18 undergo [ F]Alfatide PET/CT or [ F]FDG PET/CT scans before surgery at Shandong Cancer Hospital from May 2011 to July 2017. SUVs and the pathological tumor-node-metastasis (pTNM) stages of primary tumors and metastatic lymph nodes (LNs) were measured and confirmed pathologically. Immunohistochemical (IHC) staining for integrin αvβ3 was performed on tumor samples (both primary tumors and metastatic LNs) collected from nine patients. Results: Of 61 patients who underwent PET/CT scans, 46 then underwent curative surgery and 18 18 were included in our analysis (n = 21 for [ F]Alfatide PET/CT and n = 25 for [ F]FDG PET/CT). 18 18 No significant differences in the SUV
Molecular Imaging and Biology – Springer Journals
Published: Jun 4, 2018
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