Relationship between alcohol metabolism and chemotherapy-induced emetic events in breast cancer patients

Relationship between alcohol metabolism and chemotherapy-induced emetic events in breast cancer... Breast Cancer (2017) 24:702–707 DOI 10.1007/s12282-017-0761-4 ORIGINAL ARTICLE Relationship between alcohol metabolism and chemotherapy- induced emetic events in breast cancer patients 1 1 2 3 • • • • Toshitaka Uomori Yoshiya Horimoto Kaoru Mogushi Joe Matsuoka Mitsue Saito Received: 19 October 2016 / Accepted: 8 February 2017 / Published online: 20 February 2017 The Japanese Breast Cancer Society 2017 Abstract institution. ALDH2 genotypes were analyzed employing Background Chemotherapy-induced nausea and vomiting the smart amplification process in peripheral blood (CINV) can negatively affect quality of life and treatment samples. compliance in breast cancer patients. Habitual alcohol Results The wild type (ALDH2*1/*1), heterozygote consumption reportedly shows an inverse correlation with (ALDH2*1/*2), and mutant homozygote (ALDH2*2/*2) CINV, though the underlying mechanism is unknown. genotypes were found in 53, 44, and 3% of patients, Acetaldehyde dehydrogenase 2 (ALDH2), one of the two respectively. Complete response, i.e., no vomiting without ALDH isozymes, is reportedly the major factor among rescue anti-emetics, was more frequent in patients who several genetic polymorphisms possibly affecting alcohol habitually consumed alcohol than in those who did not metabolism. More than 40% of Japanese have ALDH2 (p = 0.036). This trend remained only in ALDH2 mutations, while almost all Westerners http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Breast Cancer Springer Journals

Relationship between alcohol metabolism and chemotherapy-induced emetic events in breast cancer patients

Loading next page...
 
/lp/springer_journal/relationship-between-alcohol-metabolism-and-chemotherapy-induced-ErRovGI8t1
Publisher
Springer Japan
Copyright
Copyright © 2017 by The Japanese Breast Cancer Society
Subject
Medicine & Public Health; Surgical Oncology; Oncology; Surgery; Cancer Research
ISSN
1340-6868
eISSN
1880-4233
D.O.I.
10.1007/s12282-017-0761-4
Publisher site
See Article on Publisher Site

Abstract

Breast Cancer (2017) 24:702–707 DOI 10.1007/s12282-017-0761-4 ORIGINAL ARTICLE Relationship between alcohol metabolism and chemotherapy- induced emetic events in breast cancer patients 1 1 2 3 • • • • Toshitaka Uomori Yoshiya Horimoto Kaoru Mogushi Joe Matsuoka Mitsue Saito Received: 19 October 2016 / Accepted: 8 February 2017 / Published online: 20 February 2017 The Japanese Breast Cancer Society 2017 Abstract institution. ALDH2 genotypes were analyzed employing Background Chemotherapy-induced nausea and vomiting the smart amplification process in peripheral blood (CINV) can negatively affect quality of life and treatment samples. compliance in breast cancer patients. Habitual alcohol Results The wild type (ALDH2*1/*1), heterozygote consumption reportedly shows an inverse correlation with (ALDH2*1/*2), and mutant homozygote (ALDH2*2/*2) CINV, though the underlying mechanism is unknown. genotypes were found in 53, 44, and 3% of patients, Acetaldehyde dehydrogenase 2 (ALDH2), one of the two respectively. Complete response, i.e., no vomiting without ALDH isozymes, is reportedly the major factor among rescue anti-emetics, was more frequent in patients who several genetic polymorphisms possibly affecting alcohol habitually consumed alcohol than in those who did not metabolism. More than 40% of Japanese have ALDH2 (p = 0.036). This trend remained only in ALDH2 mutations, while almost all Westerners

Journal

Breast CancerSpringer Journals

Published: Feb 20, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off