Regulatory Function of Na-Ca Exchange in the Heart: Milestones and Outlook

Regulatory Function of Na-Ca Exchange in the Heart: Milestones and Outlook J. Membrane Biol. 168, 107–130 (1999) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1999 Topical Review M. Egger, E. Niggli Department of Physiology, University of Bern, Bu ¨ hlplatz 5, CH-3012 Bern, Switzerland Received: 14 August 1998/Revised: 14 December 1998 Milestones Lederer, 1985; Allen, Noble & Reuter, 1989; Blaustein, DiPolo & Reeves, 1991; Philipson, Nicoll & Li, 1993; Hilgemann, Philipson & Vassort, 1996; Khananshvili, + 2+ The Na /Ca exchange is a countertransport mechanism 1998). located in the cell membrane of almost every mammalian The purpose of this review is to present an introduc- 2+ cell type. It can transport Ca across the membrane and + 2+ tory overview for readers entering the field of Na /Ca 2+ against the electrochemical gradient for Ca by utilizing exchange research. The emphasis is on the role of the the electrochemical gradient for Na . Thirty years ago a + 2+ 2+ Na /Ca exchanger in cardiac Ca signaling and its + 2+ Na /Ca exchange mechanism was identified in the contribution to membrane current in cardiac myocytes. squid giant axon and in heart muscle (Baker et al., 1968; In addition, we point out several ongoing controversies 45 2+ The Journal of Membrane Biology Springer Journals

Regulatory Function of Na-Ca Exchange in the Heart: Milestones and Outlook

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Copyright © Inc. by 1999 Springer-Verlag New York
Life Sciences; Biochemistry, general; Human Physiology
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