Psychopharmacology (2017) 234:2777–2792 DOI 10.1007/s00213-017-4670-1 ORIGINAL INVESTIGATION Regulation of sustained attention, false alarm responding and implementation of conditional rules by prefrontal GABA transmission: comparison with NMDA transmission 1 1 1 Meagan L. Auger & Juliet Meccia & Stan B. Floresco Received: 1 March 2017 /Accepted: 8 June 2017 /Published online: 24 June 2017 Springer-Verlag GmbH Germany 2017 Abstract response latencies. Visual and auditory conditional discrimi- Rationale Both prefrontal cortex (PFC) GABA and NMDA nation was impaired by 50 ng, but not 12.5 ng of bicuculline. transmission regulate attentional processes, yet how they may Conclusions These findings highlight a key role for PFC differentially regulate signal detection or other aspects of at- GABA transmission in reducing sensitivity to distractors dur- tention is unclear. ing attentional performance. Furthermore, they reveal that dis- Objectives We examined PFC GABA and NMDA receptor ruption of GABA signaling can interfere with the ability to regulation of attention using a sustained attention task (SAT) implement conditional rules. permitting identification of distinct forms of impairments. As . . . . this task requires implementation of conditional rules, we also Keywords Attention Prefrontal cortex GABA NMDA investigated how reducing PFC GABA transmission affected Conditional discriminations Schizophrenia performance of
Psychopharmacology – Springer Journals
Published: Jun 24, 2017
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