Regulation of Multimeric Structure of NO-synthase as a New Factor of Organogenesis

Regulation of Multimeric Structure of NO-synthase as a New Factor of Organogenesis The effect of NO on organogenesis in Drosophila is discussed. A new model of regulation of the activity of NO-producing enzyme, NO synthase is described, which takes into account endogenous synthesis of its reduced isoform. The reduced isoform of NO synthase is capable of suppressing the enzymatic activity of full-sized NO synthase during formation of a heterodimer in vivo and in vitro. The reduced form of this enzyme inhibits the antiproliferative effect of the full-sized NO synthase isoform during formation of eye structure in Drosophila by affecting the pathways of cell cycle regulation. The reduced form of NO synthase is an endogenous dominant-negative factor of regulation of the NO synthase activity in development of Drosophila. Russian Journal of Developmental Biology Springer Journals

Regulation of Multimeric Structure of NO-synthase as a New Factor of Organogenesis

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Copyright © 2005 by MAIK "Nauka/Interperiodica"
Life Sciences; Developmental Biology; Animal Anatomy / Morphology / Histology
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