Regulation of Current Flow through Ryanodine Receptors by Luminal Ca2+

Regulation of Current Flow through Ryanodine Receptors by Luminal Ca2+ J. Membrane Biol. 159, 179–185 (1997) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1997 Topical Review 2+ Regulation of Current Flow through Ryanodine Receptors by Luminal Ca R. Sitsapesan, A.J. Williams Imperial College School of Medicine at the National Heart & Lung Institute, Dovehouse Street, London SW3 6LY, UK Received: 3 March 1997/Revised: 28 March 1997 Introduction triggered. In skinned cardiac cells, Fabiato & Fabiato [7] 2+ 2+ demonstrated that the magnitude of Ca -induced Ca - 2+ 2+ Ca release from intracellular stores occurs through two release (CICR) was increased as the Ca loading of the main classes of intracellular membrane channel; the sar- SR was increased. Fabiato later proposed two types of 2+ 2+ coplasmic reticulum (SR) Ca -release channel/ryan- CICR in skinned cardiac cells: (i) a time- and Ca - odine receptor (RyR), or the inositol 1,4,5-trisphosphate dependent activation which is triggered by the rapid in- 2+ (InsP ) receptor. Under physiological conditions the crease of [Ca ] at the cytoplasmic side of the SR and (ii) 2+ 2+ opening of both types of channel is thought to be trig- the spontaneous release of Ca which requires Ca 2+ gered by a signal The Journal of Membrane Biology Springer Journals

Regulation of Current Flow through Ryanodine Receptors by Luminal Ca2+

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Copyright © Inc. by 1997 Springer-Verlag New York
Life Sciences; Biochemistry, general; Human Physiology
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