Mammalian Genome 8, Brief Data Reports 871 5. Nash P, Opas M, Michalak M (1994) Mol Cell Biochem 135, 71- Jackson BSS Chromosome 5 R SE Tbx3 NDNDDNND 6. Hebert DN, Foellmer B, Helenius A (1996) EMBO J 15, 2961-2968 9.57 3.03 D5Hun11 9149149149 1.06 1.06 7. Helenius A, Trombetta ES, Hebert DN, Simons JF (1997) Trends Cell Aao monmmmmmo 2.13 1.49 Biot 7, 193-200 Limk, 9   9 9  9  3.19 1.81 8. Spiro RG, Zhu Q, Bhoyroo V, Soling H-D (1996) J Biol Chem 271, zps NDDNNDDm 11588-11594 35 44 4 5 1 2 2 1 9. Hammond C, Braakman I, Helenius A (1994) Proc Natl Acad Sci USA 91,913-917 10. Ware FE, Vassilakos A, Peterson PA, Jackson MR, Lehrman MA, Williams DB (1995) J Biol Chem 270, 4697-4704 11. Mouse Genome Database. Mouse Genome Informatics Project, The Jackson Laboratory, Bar Harbor, Maine. World Wide Web (URL:http://www.informatics.j ax.org) (1995). B Chromosome 5 Regional localization of the mouse argininosuccinate lyase gene to Chromosome 5 -- D5Bir19 Pbpr -- D5Hun9 D5HunlO Ftna Nosl Tbx3 V. Reid Sutton, Yanzhen Pan, William J. Craigen -- D5Xrf184 Department of Molecular and Human Genetics, $830, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA -- D5Xrf378 Received: 5 June 1997 / Accepted: 20 June 1997 D5Hun11 I 5cM Species: Mouse Asl Locus name: Argininosuccinate lyase lapt3 Limkl Locus symbol: Asl D5Bir21 Por Ywhag Map position: centromere-Tbx3-(9.57 +_ 3.03)-D5Hunl l-(1.06 +_ D5Hun12 Zp3 1.06)-Asi-(2.13 +_ 1.49)-Limkl-(3.19 + 1.81)-Zp3. Azgpl Epo Pcolce Cdx2 Fan1 Pdxl Prkarlb Ftacl Pmv12 Method of mapping: Determined from 93 interspecific backcross progeny derived from matings of (C57BL/6JEi � Mus spretus/ DSBir22 Ei)F 1 x Mus spretus/Ei (Jackson BSS) as described . Fig. 1. Mouse chromosomal mapping of Asl. Panel A: the relevant loci are Database deposit information: MGD accession number MGD- listed on the left of the figure. Black boxes indicate the C57BL/6J allele, JNUM-40407. and the white boxes the M. spretus allele. The number of offspring inher- Molecular reagents: 0.5-kb intronic Nco 1 DNA fragment obtained iting each haplotype is listed at the bottom of each column. On the right of from screening a 129sv/ev genomic library with a 530-bp mouse the figure is the frequency of recombination (R) between the listed loci. eDNA probe derived from mouse liver RNA via RT-PCR by use Panel B provides a more complete representation of the genetic map of the of primers based upon the rat argininosuccinate lyase eDNA se- distal portion of Chr. 5 (data available at http://www.jax.org/resources/ quence (5'-GTCCTGCGCACCGTCCAAACACT-3',5'-GGC- documents/cmdata). AAACCTACTCAAAACTCTCC-3 ') . Allele detection: RFLP analysis of an EcoR1 polymorphism. M. spretus-specific band is 5.0 kb, while the C57BL/6J-specific band Medicine Child Health Research Center (NICHD IP30-HD27823). Thanks is 6.0 kb. to Lucy Rowe and Mary Barter at The Jackson Laboratory for their help with the BSS panel. Previously identified homologs: The human form of argininosuc- cinate lyase was localized to human Chromosome (Chr) 7q21.3-22 by somatic cell hybrid analysis [3-5]. Asl has also been mapped to References 1. Rowe L, Nadeau J, Turner R, Frankel W, Letts V, Eppig J, Ko M, syntenic group U8 in a cow-rodent somatic cell hybrid panel . Thurston S, Birkenmeier E (1994) Mamm Genome 5, 253-274 Discussion: Argininosuccinate lyase catalyzes the formation of 2. Matuo S, Tatsuno M, Kobayashi K, Saheki T, Miyata T, lwanaga S, fumarate and arginine from argininosuccinic acid, both in the urea Amaya Y, Mori M (1988) FEBS Lett 234, 395-399 cycle and in the reformation of arginine in the nitric oxide cycle 3. O'Brien W, Mclnnes R, Kalumuck K, Adcock M (1986) Proc Natl . Deficiency of the enzyme in humans leads to protein intoler- Acad Sci USA 83, 7211-7215 ance, hyperammonemia, and a variably progressive liver fibrosis 4. Naylor SL, Klebe RJ, Shows TB (1978) Proc Natl Acad Sci USA 75, . The mouse Asl gene has previously been localized to mouse 6159-6162 Chr 5 by isozyme analysis of mouse-hamster somatic cell hybrids 5. Todd S, McGill J, Moore C, Weider I, Naylor S (1989) Genomics 4, ]9], and although no regional assignment has previously been es- 53-59 tablished for the mouse, on the basis of comparative mapping data 6. Womack J, Threadgill D, Moll Y, Faber L, Foreman M, Dietz A, it has been suggested that Asl is syntenic with Gus-Morl . Using Tobin T, Skow L, Zneimer S, Gallagher D, Rogers D (1989) Cytogenet interspecific backcross analysis, we have refined the map location Cell Genet 51, 1109 (Abstr) (Fig. 1) and demonstrate that the syntenic relationships observed 7. Nagasaki A, Gotoh T, Takeya M, Yu Y, Takiguchi M, Matsuzaki H, with the human ASL gene on Chr 7 are conserved in the mouse, Takatsuki K, Moil M (1996) J Biol Chem 271, 2658-2662 with linkage to Tbx3, DSHunl l, Limkl, and Zp3. 8. Brusilow SW, Horwich AL (1995) Urea cycle enzymes, In The Meta- bolic and Molecular Bases of Inherited Disease, Schriver, Beaudet, Acknowledgments: This work was supported by the Baylor College of Sly, Valle, eds., 7th edn, (New York: McGraw-Hill), pp 1187-1232 9. Lalley P, Naylor S, Shows T (1979) Cytogenet Cell Genet 25, 178 Correspondence to: W.J. Craigen (Abstr)
Mammalian Genome – Springer Journals
Published: Mar 24, 2009
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